丹参注射液联合复合乳酸菌胶囊治疗溃疡性结肠炎的疗效评估

Evaluation of curative effects of Danshen Injection combined with lactic acid bacteria capsule in treatment of ulcerative colitis

目的评估丹参注射液联合复合乳酸菌胶囊治疗活动期溃疡性结肠炎(UC)的疗效。方法64例UC患者随机分为对照组和治疗组,每组32例。对照组给予美沙拉嗪肠溶片4.0g/d,口服,分4次;复合乳酸菌胶囊2粒(0.66g),3次/d,口服。治疗组在对照组基础上给予丹参注射液20ml,加入5%葡萄糖液250ml中,静脉滴注,1次/d,观察4周后观察疗效。结果治疗2周后2组患者排便次数差异无统计学意义(P>0.05);治疗4周后治疗组排便次数明显少于对照组,差异有统计学意义(P<0.05)。治疗2周及治疗4周后治疗组便血情况较对照组明显减轻,差异有统计学意义(P<0.05)。治疗4周后通过Mayo评分法评估疗效,治疗组疗效明显优于对照组,差异有统计学意义(P<0.05)。2组治疗2周及4周后,血沉水平较治疗前均有改善,差异有统计学意义(P<0.05)。治疗2周后,2组患者血清血小板(PLT)水平差异无统计学意义(P>0.05);治疗4周后,治疗组PLT明显小于对照组,差异有统计学意义(P<0.05。2组患者不良反应发生情况差异无统计学意义(P>0.05)。治疗组发生肝肾功能异常例数与对照组比较差异无统计学意义(P>0.05)。结论丹参注射液及复合乳酸菌胶囊联合应用对UC治疗效果明显,值得推广。

Objective To investigate the curative effects of Danshen Injection combined with lactic acid bacteria capsule in treatment of ulcerative colitis(UC). Methods A total of 64 patients with UC were randomly divided into control group and treatment group,with 32 cases in each group. The patients in control group were treated by oral mesalazine4. 0 g/d,which was divided four times,and complex lactic acid bacteria capsules 2 pills(0. 66 g),three times a day,however,the patients in treatment group,on the basis of control group,were treated by Danshen injection 20 ml,adding 5 % glucose solution to 250 ml,once a day by intravenous drip. After 4-wek treatment,the therapeutic effects were observed and compared between the two groups. Results After 2-week treatment,there was no significant difference in the frequency of defecation between the two groups(P > 0. 05),however,after 4-wek treatment,the frequency of defecation in treatment group was significantly lower than that in control group(P < 0. 05). After 2-week and 4-week treatment,the hemafecia status in treatment group was superior to that in control group(P < 0. 05). After 4-week treatment,the therapeutic effects according to Mayo score in treatment group were superior to those in control group(P < 0. 05). After 2-week and 4-week treatment,the levels of ESR were significantly improved in both groups,as compared with those before treatment(P < 0. 05),however,there were no significant differences in serum levels of platelet(PLT) after 2-week treatment between the two groups(P > 0. 05),but the serum levels of PLT after 4-week treatment in treatment group were significantly lower than those in control group(P <0. 05). There were no significant differences in the incidence rates of adverse reactions and liver and kidney function abnormality between the two groups(P > 0. 05). Conclusion The therapeutic effects of Danshen injection combined with compound lactic acid bacteria capsule on Uc significant,which is worthy of promotion in clinical practice.