急性脑梗死患者经导管选择性脑动脉内介入溶栓术治疗的回顾性研究

Retrospective study of transcatheter selective cerebral intra-arterial interventional thrombolysis in treatment on patients with acute cerebral infarction

目的探讨经导管选择性脑动脉内介入溶栓术在急性脑梗死中的应用价值。方法选取2017年10月至2018年10月急性脑梗死患者80例的临床资料进行回顾性分析,根据治疗方法分为对照组(n=40)和研究组(n=40)。对照组采取常规药物治疗,研究组在对照组基础上采取经导管选择性脑动脉内介入溶栓术。比较2组治疗前后神经功能(NIHSS)及临床症状(mRS)分值、临床疗效、血管再通情况。结果治疗后2组NIHSS分值及mRS分值较治疗前降低,且研究组低于对照组(P<0.05);研究组总有效率为92.5%高于对照组的75.0%(P<0.05);研究组血管完全再通率为65.0%高于对照组的42.5%(P<0.05);随访3个月,研究组患者恢复优良率为87.5%明显高于对照组的65.0%(P<0.05)。结论采取经导管选择性脑动脉内介入溶栓术治疗急性脑梗死可有效缓解患者临床症状,提高治疗效果及血管再通率,促使患者神经功能及早恢复。

Objective To investigate the application value of transcatheter selective cerebral intra-arterial interventional thrombolysis in treatment of acute cerebral infarction. Methods The clinical data of 80 patients with acute cerebral infarction who were treated in our hospital from October 2017 to October 2018 were retrospectively analyzed,who were divided into control group(n = 40) and research group(n = 40) according to different therapeutic methods. The patients control group were treated by conventional drugs,however,the patients in research group,on the basis of control group,were treated by transcatheter selective cerebral intra-arterial thrombolysis. The scores of neurological function(NIHSS) and clinical symptoms(mRS),the clinical efficacy,the vascular recanalization before and after treatment were measured and compared between the two groups. Results After treatment,the scores of NIHSS and mRS in both groups were significantly lower than those before treatment,moreover the scores of NIHSS and mRS in research group were significantly lower than those in control group(P < 0. 05). The total effective rate in research group was significantly higher than that in control group(92. 5% vs75%,P < 0. 05). Moreover the total recanalization rate of blood vessels in research group was significantly higher than that in control group(65% vs 42. 5%,P < 0. 05). In addition,after 3-month follow-up,the recovery excellent rate in research group was significantly higher than that in control group(P < 0. 05). Conclusion The transcatheter selective cerebral intraarterial thrombolysis in treatment of acute cerebral infarction can effectively relieve clinical symptoms of patients,improve the therapeutic effects and vascular recanalization rate,which can promote the neural function recovery of patients as soon as possible.