期刊文献+

皮肤再生医学相关技术在皮肤科学的应用前景 被引量:1

Application Prospect of Correlation Technique of Skin Regenerative Medicine in Dermatology
下载PDF
导出
摘要 人表皮干细胞主要来源于表皮,尤其在皮肤创伤后修复和再生方面具有十分重要的功能和作用。皮肤再生医学是再生医学的重要组成部分,也是皮肤科学与再生医学的交叉学科,是两者的完美结合。作为皮肤再生医学的主要特色,表皮干细胞相关技术、基因治疗及3D生物打印等前沿技术的研究和应用在一定程度上弥补和解决了当前和未来皮肤科学治疗领域,尤其在重症皮肤疾病和严重皮肤创伤等治疗方面的局限与不足,它们也是皮肤科治疗领域发展最有潜力的治疗技术。虽然皮肤再生医学仍会面临诸多问题和挑战,但其未来发展前景广阔。 Human epidermal stem cells mainly are derived from epidermis and play an important role in its function and effect on the skin repair and regeneration after skin wound. The skin regenerative medicine, an important component of regenerative medicine, is a cross discipline of dermatology and regenerative medicine.As the major special feature of skin regenerative medicine, researching and applying the advanced technology of epidermal stem cells, gene therapy and 3-dimensional bioprinting can solve and make up for insufficiency of therapeutics on dermatology currently and in the future, especially in severe cases and skin wound. They are the best potential therapic technology on dermatology. Although there are also a lot of problems and challenges, the skin regenerative medicine has a great prospect for its development.
作者 杨扬 梁晓博 YANG Yang;LIANG Xiao-bo(Department of Dermatology,the No.8th Medical Center of the PLAGH,Beijing 100091,China)
出处 《中国美容医学》 CAS 2019年第7期170-173,共4页 Chinese Journal of Aesthetic Medicine
关键词 皮肤再生医学 表皮干细胞 基因治疗 3D生物打印 skin regenerative medicine epidermal stem cell gene therapy 3D bioprinting
  • 相关文献

参考文献2

二级参考文献34

  • 1Harding CR.The stratum corneum: structure and function in health and disease[J). Dermatol Ther,2004,17 Suppll:6-15.
  • 2Palmer CN,Irvine AD,Terron-Kwiatkowski A,et al. Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis [J).Nat Genet, 2006,38(4):441-446.
  • 3Nemes Z,Steinert PM. Bricks and mortar of the epidermal barrier[J]. Exp Mol Med,1999,31(1): 5-19.
  • 4presland RB,Coulombe PA,Eckert RL,et al.Barrier function in transgenic mice overexpressing K16, involucrin, and filaggrin in the suprabasal epidermis[J].J Invest Dermatol,2004,123(3):603-606.
  • 5Candi E,Schmidt R,Melino G.The cornified envelope: a model of cell death in the skin[J].Nat Rev Mol Cell Biol,2005,6(4):328-340.
  • 6Matsuki M,Yamashita F,Ishida-Yamamoto A,et al.Defective stratum corneum and early neonatal death in mice lacking the gene for transglutaminase 1 (keratinocyte transglutaminase)[J].Proc Nat! Acad Sci USA,I998,95(3):1044-1049.
  • 7Huber M,Rettler I,Bernasconi K,et al.Mutations of keratinocyte transglutaminase in lamellar ichthyosis [J].Science,1995,267 (5197): 525-528.
  • 8Koch PJ,de Viragh PA,Scharer E,et al.Lessons from loricrin-deficient mice: compensatory mechanisms maintaining skin barrier function in the absence of a major cornified envelope protein[J].J Cell Biol,2000, 151 (2):389-400.
  • 9Egberts F,Heinrich M,Jensen JM,et al.Cathepsin D is involved in the regulation of transglutaminase I and epidermal differentiation [J].J Cell Sci,2004,117(Pt 11):2295-2307.
  • 10Maestrini E,Monaco AP,McGrath JA,et al.A molecular defect in loricrin, the major component of the cornified cell envelope, underlies Vohwinkel's syndrome[J].Nature Genet, 1996, 13(1 ):70-77.

共引文献33

同被引文献1

引证文献1

二级引证文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部