维生素B6联合左乙拉西坦治疗小儿癫痫的有效性及安全性评价

Effectiveness and Safety of Vitamin B6 Combined with Levetiracetam in the Treatment of Epilepsy in Children

目的探究和评价维生素B6联合左乙拉西坦治疗小儿癫痫的有效性及安全性。方法选择我院2017年3月~2018年3月收治的90例癫痫患儿作为研究对象,随机分为对照组和研究组各45例。对照组采用左乙拉西坦治疗,研究组采用维生素B6联合左乙拉西坦治疗,对比两组患者治疗期间的不良反应发生率及治疗总有效率。结果研究组治疗期间的不良反应发生率(4.4%)显著低于对照组(31.1%),差异有统计学意义(P<0.05);研究组治疗总有效率(86.7%)显著高于对照组(68.9%),差异有统计学意义(P<0.05)。结论采用维生素B6联合左乙拉西坦治疗小儿癫痫不仅能改善患儿临床症状,降低癫痫发作频次,且还能降低患儿因单用左乙拉西坦引起的行为异常,是一种安全、高效的组合治疗方案。

Objective To investigate and evaluate the efficacy and safety of vitamin B6 combined with levetiracetam in the treatment of children with epilepsy.Methods 90 children with epilepsy admitted to our hospital from March 2017 to March 2018 were selected as subjects.They were randomly divided into control group and study group,45 cases in each group.The control group was treated with levetiracetam. The study group was treated with vitamin B6 plus levetiracetam to compare the incidence of adverse reactions and the total effective rate of treatment during the treatment.Results The incidence of adverse reactions during treatment(4.4%) was significantly lower in the study group than in the control group (31.1%).The total effective rate of treatment in the study group (86.7%) was significantly higher than that in the control group(68.9%).The two groups were statistically significant(P<0.05).Conclusion Vitamin B6 combined with levetiracetam in children with epilepsy can not only improve the clinical symptoms and reduce the frequency of seizures,but also reduce the behavioral abnormalities caused by levetiracetam alone.Therefore,it is a safe and efficient combination therapy.