围绝经期妇女血清性激素水平与Th1/Th2平衡及内皮功能的关系

Relationship between serum sex hormone level and Th1/Th2 balance and endothelial function in perimenopausal women

目的研究围绝经期妇女血清性激素水平与Th1/Th2平衡及内皮功能的关系。方法选取2016年3月~2018年3月于四川省德阳市妇幼保健院(以下简称“我院”)就诊的围绝经期妇女40例作为围绝经期组,绝经期妇女40例作绝经期组,同期于我院接受体检的健康妇女40名作为正常对照组。分别比较三组妇女血清性激素指标水平,Th1/Th2相关细胞因子水平,内皮损伤标志物水平,并分析其相关性。结果正常对照组、围绝经期组、绝经期组血清雌二醇(E2)水平呈逐渐降低趋势,血清促卵泡激素(FSH)水平呈逐渐升高趋势,三组血清E2、FSH比较差异有统计学意义(P <0.05)。正常对照组、围绝经期组、绝经期组血清白细胞介素-2(IL-2)与γ干扰素(IFN-γ)水平均呈逐渐升高趋势,而IL-4与IL-10水平均呈逐渐降低趋势,三组血清IL-2、IFN-γ、IL-4与IL-10比较差异有统计学意义(P <0.05)。正常对照组、围绝经期组、绝经期组血清一氧化氮(NO)水平呈逐渐降低趋势,而血清内皮素-1(ET-1)水平呈逐渐升高趋势,三组NO、ET-1比较差异有统计学意义(P <0.05)。经Pearson相关性分析显示:围绝经期妇女血清E2与IL-2、IFN-γ、ET-1均呈负相关关系,而与IL-4、IL-10、NO均呈正相关关系;血清FSH与IL-2、IFN-γ、ET-1均呈正相关关系,而与IL-4、IL-10、NO均呈负相关关系(均P <0.05)。结论围绝经期妇女血清性激素水平会对Th1/Th2平衡造成影响,且会导致内皮功能损伤。

Objective To study the relationship between serum sex hormone level and Th1/Th2 balance and endothelial function in perimenopausal women. Methods 40 perimenopausal women admitted in Deyang Maternal and Child Health Hospital in Sichuan Province ("our hospital" for short) from March 2016 to March 2018 were selected as perimenopausal group, 40 menopausal women served as menopausal group. At the same time, 40 healthy women who underwent physical examination in our hospital served as normal control group. The level of serum sex hormone, Th1/Th2 related cytokines and endothelial injury markers was compared among three groups of women, and their correlation was analyzed. Results The level of serum estradiol (E2) in normal control group, perimenopausal group and menopausal group decreased gradually. The level of serum follicle stimulating hormone (FSH) increased gradually, and the difference of serum E2 and FSH among three groups was significant (P < 0.05). Serum level of interleukin-2 (IL-2) and interferon-γ(IFN-γ) increased gradually in normal control group, perimenopausal group and menopausal group, while level of IL-4 and IL-10 decreased gradually. There was significant difference in serum level of IL-2, IFN-γ, IL-4 and IL-10 between each group (P < 0.05). The level of serum nitric oxide (NO) decreased gradually in normal control group, perimenopausal group and menopausal group, while the level of serum endothelin-1 (ET-1) increased gradually. There was significant difference in NO and ET-1 among groups (P < 0.05). Pearson correlation analysis showed that serum E2 was negatively correlated with IL-2, IFN-γ and ET-1, but positively correlated with IL-4, IL-10 and NO in perimenopausal women. Serum FSH was positively correlated with IL-2, IFN-γ and ET-1, but negatively correlated with IL-4, IL-10 and NO (all P < 0.05). Conclusion Serum sex hormone level in perimenopausal women may affect Th1/Th2 balance and lead to endothelial dysfunction.