散结镇痛胶囊联合阿奇霉素治疗慢性盆腔炎临床研究

Clinical Study on Sanjie Zhentong Capsules Combined with Azithromycin in the Treatment of Chronic Pelvic Inflammation

目的探讨散结镇痛胶囊联合阿奇霉素治疗慢性盆腔炎的临床疗效。方法选取湖北省妇幼保健院2015年1月至2018年3月收治的慢性盆腔炎患者105例,按随机数字表法分为对照组(52例)和观察组(53例)。两组患者均口服阿奇霉素片,观察组患者加服散结镇痛胶囊,均连续服用7d。结果观察组总有效率为96.23%,明显高于对照组的82.69%(P<0.05);与治疗前比较,两组患者治疗后的丙二醛(MDA)、晚期氧化蛋白产物(AOPP)、肿瘤坏死因子-α(TNF-α)水平均显著下降(P<0.05),且观察组显著低于对照组(P<0.05);超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、白细胞介素2(IL-2)、白细胞介素10(IL-10)水平均显著升高(P<0.05),且观察组显著高于对照组(P<0.05);观察组不良反应发生率为1.89%,明显低于对照组的15.38%(P<0.05)。结论散结镇痛胶囊联合阿奇霉素治疗慢性盆腔炎,可减轻氧化应激和炎性应激反应,并可明显减少不良反应。

Objective To investigate the clinical efficacy of Sanjie Zhentong Capsules combined with azithromycin in the treatment of chronic pelvic inflammation.Methods Totally 105 patients with chronic pelvic inflammation admitted to Hubei Maternal and Child Health Hospital from January 2015 to March 2018 were selected and divided into the control group(52 cases)and the observation group(53 cases)according to the random number table method.The patients in the two groups took Azithromycin Tablets orally,while the patients in the observation group took Sanjie Zhentong Capsules on the basis of the control group.Both groups were treated continuously for 7 d.Results The total effective rate of the observation group was 96.23%,which was significantly higher than 82.69%of the control group(P<0.05).Compared with those before treatment,the levels of malondialdehyde(MDA),advanced oxidative protein product(AOPP)and tumor necrosis factor-α(TNF-α)in the two groups were significantly decreased after treatment(P<0.05),and those in the observation group were sinificantly lower than those in the control group(P<0.05).The levels of superoxide dismutase(SOD),glutathione peroxidase(GSH-Px),interleukin-2(IL-2),IL-10 in the two groups were significantly increased after treatment(P<0.05),and those in the observation group were significantly higher than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was 1.89%,which was significantly lower than 15.38%in the control group(P<0.05).Conclusion Sanjie Zhentong Capsules combined with azithromycin in the treatment of chronic pelvic inflammation can alleviate oxidative stress and inflammatory emergency reaction,and also can significantly reduce adverse reactions.