尿毒症患者桡动脉血管钙化因素的相关性研究

Correlation study of calcification factors in radial artery in uremia patients

目的探讨尿毒症患者桡动脉血管钙化因素的相关性。方法选取2015年1月~2016年12月我院收治的60例尿毒症患者作为研究对象,取桡动脉血管进行von Kossa钙化染色,并行双手X线片、拍摄骨盆,计算血管钙化评分,测量其血压指标,检测其磷、钙等血生化指标及全段甲状旁腺素的水平,并对血管钙化的相关性予以分析。结果本研究中共29例患者发生桡动脉血管钙化,占48.33%,发生桡动脉血管钙化患者的血磷、钙磷乘积、碱性磷酸酶、全段甲状旁腺激素、血管钙化率、血管钙化积分均高于未发生桡动脉血管钙化患者,差异有统计学意义(P<0.05),发生桡动脉血管钙化患者的年龄、性别、血清总钙、血清肌酐与未发生桡动脉血管钙化患者比较,差异无统计学意义(P>0.05);将血管钙化作为因变量,多元线性回归研究结果提示,高水平的血磷、全段甲状旁腺激素、血管钙化率、碱性磷酸酶、钙磷乘积与血管钙化的形成存在正相关关系(r=0.503、0.281、0.519、0.542、0.451,P<0.05)。结论尿毒症患者桡动脉血管钙化发生较为普遍,血磷、血管钙化率、碱性磷酸酶、钙磷乘积与尿毒症患者桡动脉血管钙化的形成存在显著相关。

Objective To investigate the correlation of calcification factors of radial artery in uremia patients. Methods From January 2015 to December 2016, 60 cases of uremic patients treated in our hospital were selected as the research objects. The von Kossa staining for radial artery blood vessel, and X-ray film for both hands and pelvis was photographed. The vascular calcification score was calculated, blood pressure indexes were measured, blood biochemical indexes such as phosphorus and calcium were detected, and the level of whole parathyroid hormone was detected, and the correlation of vascular calcification was analyzed. Results In this study, a total of 29 patients developed radial artery calcification, accounted for 48.33%. The serum phosphorus, calcium phosphate product, alkaline phosphatase,parathyroid hormone, vascular calcification rate and vascular calcification score of the patients with radial artery calcification were all higher than those patients without radial artery calcification, and the differences were statistically significant(P<0.05). There was no significant difference in age, gender, serum total calcium and serum creatinine between patients with and without radial artery calcification(P>0.05). Vascular calcification was taken as the dependent variable, and the results of multiple linear regression suggested that there were positive correlation between high level of serum phosphorus, total parathyroid hormone vascular calcification rate, alkaline phosphatase calcium phosphate product and the formation of vascular calcification(r=0.503, 0.281, 0.519, 0.542, 0.451, P<0.05). Conclusion Calcification of the radial artery is common in uremic patients, and there is a significant correlation between serum phosphorus, vascular calcification rate, alkaline phosphatase and calcium phosphorus product and the formation of calcification of the radial artery in uremic patients.