颈动脉斑块内新生血管的临床意义

The effect of neovascularization in carotid plaque on clinical manifestations

目的探讨颈动脉粥样斑块内新生血管的临床意义。方法收集2016年1至8月中日友好医院心脏血管外科52例患者颈动脉内膜剥脱术后的斑块。依据临床症状分为症状组和无症状组。所有手术标本均进行HE染色和Movat特殊染色,并在显微镜下分别统计新生血管密度、横截面积大小、分布部位和形态。结果症状组和无症状组的新生血管密度分别为5. 27 +0. 46和2. 30 士0. 29( P <0.001);症状组中新生血管的平均横截面积为(2. 26 ±0.21) mm2,无症状组为(1.00 ±0.48) mm2(P = 0.02);在分布范围上,症状组和无症状组分别为:基底部(3.37 ±0.46)个/mm2、(1.32±0. 16)个/mm2;肩部(3.71 ±0.42)个/mm\( 1. 56 + 0. 20)个/mm2;纤维帽(3.48 ±0.44)个/mm2、(1.55 ±0.21)个/mm2,症状组均显著大于无症状组(均P<0.001)。结论症状组中的新生血管密度和横截面积均大于无症状组,以不规则分枝状血管为主。

Objective To explore the effect of angiogenesis in carotid atherosclerotic plaque. Methods From Jan 2016 to Aug 2016, Carotid artery plaque was abtained in 52 cases after carotid endarterectomy at the Department of Cardiovascular Surgery of China-Japan Friendship Hospital. Patients were divided into symptomatic group and asymptomatic group. Specimens were stained with HE and Movat, and the density, size, distribution and morphology of neovascularization were counted. Results The density of neovascularization in the symptomatic group and the asymptomatic group were 5.27 ± 0. 46 and 2. 30 ± 0. 29, respectively (P<0. 001), the average cross-sectional area of neovascularization in the symptomatic group was (2. 26 ± 0. 21 ) mm2 and ( 1. 00 ± 0. 48 ) mm2 in the asymptomatic group ( P = 0.02). In the distribution, the symptomatic group and the asymptomatic group were 3.37 ± 0.46/ mm2 , 1.32 ± 0.16/ mm2 in basal part,3.71±0.42/ mm2, 1.56 ±0.20/ mm2 in the shoulder part, 3.48 ±0.44/ mm2, 1.55 ± 0.21/ mm2 in the fibrous cap, respectively (P<O.001). Conclusion The density and cross- sectional area of neovascularization in the symptomatic group were larger than those in the asymptomatic group, irregular branching vessels were dominant.