瑞舒伐他汀钙联合阿司匹林对缺血性脑血管病患者脑糖代谢、斑块易损性的影响

Effect of rosuvastatin calcium combined with aspirin on cerebral glycometabolism and plaque vulnerability in patients with ischemic cerebrovascular disease

目的探究瑞舒伐他汀钙联合阿司匹林对缺血性脑血管病患者脑糖代谢、斑块易损性的影响。方法72例缺血性脑血管病患者作为研究对象,按照住院号尾数单双号分为观察组和对照组,每组36例。两组患者均给予常规治疗,对照组患者在此基础上给予阿司匹林治疗,观察组患者给予瑞舒伐他汀钙联合阿司匹林治疗。观察比较两组患者的临床疗效、治疗前后的脑血糖差(A-VGlu)及颈动脉内膜-中层膜厚度(IMT)。结果经治疗后,观察组患者的总有效率为97.22%,明显高于对照组的80.56%,差异有统计学意义(χ^2=5.063,P=0.024<0.05)。治疗前,两组患者的A-VGlu、IMT比较差异均无统计学意义(P>0.05)。与治疗前相比,两组患者的A-VGlu均明显降低,颈动脉IMT均明显变薄,且观察组患者的A-VGlu(2.25±0.21)mmol/L明显低于对照组的(3.03±0.37)mmol/L,颈动脉IMT(1.19±0.11)mm明显薄于对照组的(1.40±0.15)mm,差异均有统计学意义(P<0.05)。结论将瑞舒伐他汀钙联合阿司匹林应用于缺血性脑血管病患者,可显著提升临床疗效,改善A-VGlu,致使斑块回缩,缩小狭窄,值得临床广泛应用与推广。

Objective To investigate the effect of rosuvastatin calcium combined with aspirin on cerebral glycometabolism and plaque vulnerability in patients with ischemic cerebrovascular disease.Methods A total of 72 patients with ischemic cerebrovascular disease as study subjects were divided into observation group and control group according to odd and even number of end number of hospitalization,with 36 cases in each group. Both groups received conventional therapy,and the control group also treated with aspirin.The observation group was treated with rosuvastatin calcium combined with aspirin.Observation and comparison were made on clinical efficacy,cerebral glucose difference (A-V Glu) and carotid intima-media thickness (IMT) before and after treatment in two groups.Results After treatment,the observation group had obviously higher total effective rate as 97.22% than 80.56% in the control group,and the difference was statistically significant (χ^2=5.063, P=0.024<0.05).Before treatment,both groups had no statistically significant difference in A-V Glu and IMT (P>0.05).Comparing with those before treatment,both groups had obviously lower A-V Glu and thinner IMT of carotid artery.The observation group had obviously lower A-V Glu as (2.25±0.21) mmol/L than (3.03± 0.37) mmol/L in the control group,and thinner IMT of carotid artery as (1.19±0.11) mm than (1.40±0.15) mm in the control group.Their difference was statistically significant (P<0.05).Conclusion Combination of rosuvastatin calcium and aspirin in patients with ischemic cerebrovascular disease can significantly improve the clinical efficacy,improve A-V Glu,retract plaque and narrow the stenosis,and it is worthy of wide clinical application and promotion.