宫缩乏力性产后出血治疗中应用卡前列素氨丁三醇的治疗效果研究

Study on effect of carprostol tromethamine applied in the treatment of postpartum hemorrhage due to uterine contraction

目的探讨宫缩乏力性产后出血治疗中应用卡前列素氨丁三醇的治疗效果。方法128例宫缩乏力性产后出血患者,按治疗方案不同分为对照组和观察组,各64例。对照组采用催产素进行治疗,观察组采用卡前列素氨丁三醇进行治疗。对比两组患者治疗效果、不良反应发生情况、产后出血量及24h血红蛋白下降情况。结果观察组总有效率98.44%高于对照组的89.06%,差异有统计学意义(P<0.05)。对照组产后2h出血量、产后24h出血量、产后总出血量及24h血红蛋白下降水平分别为(529.46±135.92)ml、(160.26±28.46)ml、(832.56±59.98)ml、(16.88±4.95)g/L,观察组分别为(400.93±64.92)ml、(80.26±22.15)ml、(471.01±50.62)ml、(10.69±3.89)g/L;观察组产后2h出血量、产后24h出血量、产后总出血量均少于对照组,24h血红蛋白下降水平低于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率为4.69%,低于对照组的15.63%,差异有统计学意义(P<0.05)。结论对宫缩乏力性产后出血患者应用卡前列素氨丁三醇临床价值高,可控制患者产后出血情况,减少机体损失产生,安全可行性强,保证临床整体治疗效果,符合临床需求。

Objective To discuss the treatment effect of carprostol tromethamine applied in the treatment of postpartum hemorrhage due to uterine contraction.Methods A total of 128 patients with postpartum hemorrhage due to uterine contraction were divided by different treatment methods into control group and observation group,with 64 cases in each group.The control group was treated with oxytocin,and the observation group was treated with carprostol tromethamine.Comparison were made on treatment effect,occurrence of adverse reactions,postpartum hemorrhage and 24 h hemoglobin decline between the two groups.Results The observation group had higher total effective rate as 98.44% than 89.06% in the control group,and the difference was statistically significant (P<0.05).The control group had 2 h postpartum hemorrhage,24 h postpartum hemorrhage,postpartum total hemorrhage and 24 h hemoglobin decline respectively as (529.46±135.92) ml,(160.26±28.46) ml,(832.56±59.98) ml and (16.88±4.95) g/L,which were (400.93±64.92) ml,(80.26±22.15) ml,(471.01± 50.62) ml and (10.69±3.89) g/L in observation group.The observation group had less 2 h postpartum hemorrhage, 24 h postpartum hemorrhage,postpartum total hemorrhage than the control group,and lower 24 h hemoglobin decline than the control group.Their difference was statistically significant (P<0.05).The observation group had lower incidence of adverse reactions as 4.69% than 15.63% in the control group,and the difference was statistically significant (P<0.05).Conclusion Carprostol tromethamine shows high clinical value for patients with postpartum hemorrhage due to uterine contraction,and it can control the postpartum hemorrhage,reduce the occurrence of body injury,ensure the overall clinical treatment effect and meet the clinical needs.