新活素对老年心力衰竭患者尿量及精神状态的意义研究

Study on significance of Xinhuosu on urine volume and mental state in elderly patients with heart failure

目的探讨冻干重组人脑利钠肽(商品名:新活素)对老年心力衰竭患者尿量及精神状态的意义。方法80例老年心力衰竭患者,随机分为试验组和对照组,每组40例。对照组采取常规抗心力衰竭西医治疗及对症支持治疗,试验组在对照组的基础上使用新活素进行治疗。观察并比较两组患者治疗后焦虑自评量表(SAS)、抑郁自评量表(SDS)评分及24h尿量。结果治疗后,试验组SAS、SDS评分分别为(41.68±5.37)、(16.98±4.37)分,均低于对照组的(50.99±6.45)、(23.45±5.97)分,差异具有统计学意义(P<0.05);试验组24h尿量为(1234.98±80.35)ml/24h,少于对照组的(1567.78±73.81)ml/24h,差异具有统计学意义(P<0.05)。结论使用新活素对老年心力衰竭患者进行治疗,可以明显改善心力衰竭患者24h尿量,改善患者的精神状态,提高患者生活质量,值得在临床推广。

Objective To discuss the significance of (lyophilized recombinant human brain natriuretic peptide (trade name:Xinhuosu) on urine volume and mental state in elderly patients with heart failure.Methods A total of 80 elderly patients with heart failure were randomly divided into experimental group and control group, with 40 cases in each group.The control group was treated with routine anti-heart failure Western medicine and symptomatic supportive treatment,and the experimental group was treated with neoplastin on the basis of the control group.Observation and comparison were made on self-rating anxiety scale (SAS) score,selfrating depression scale (SDS) score and 24 h urine volume after treatment between the two groups.Results After treatment,the experimental group had lower SAS and SDS score respectively as (41.68±5.37) and (16.98±4.37) points than (50.99±6.45) and (23.45±5.97) points in the control group.Their difference was statistically significant (P<0.05).The experimental group had less 24 h urine volume as (1234.98±80.35) ml/24 h than (1567.78±73.81) ml/24 h in the control group,and the difference was statistically significant (P<0.05). Conclusion Xinhuosu can obviously improve 24 h urine volume of elderly patients with heart failure,improve their mental state and quality of life.It is worthy of clinical promotion.