摘要
肝移植是终末期肝病患者最有效的治疗手段,而免疫抑制剂的应用是影响患者移植术后长期存活的关键。本文介绍了最常用的免疫抑制剂——他克莫司的作用机制,以及细胞色素P450基因多态性对他克莫司应用影响的最新研究进展。为临床上合理使用他克莫司,减少相关并发症的发生,提高肝移植患者的长期生存率提供参考。
Liver transplantation is the most effective therapeutic measure for the patients with end-stage liver diseases. The application of immunosuppressive agents is the key for the long-term survival of such patients after liver transplantation. In this study, we introduce the action of mechanism of tacrolimus, the most commonly used immunosuppressive agent and the advance in the influence of cytochrome P450 gene polymorphism on the application of tacrolimus. This study provides reference for the reasonable clinical application of tacrolimus, reducing the occurrence of tacrolimus correlated complication and increasing the long-term survival rate of patients after liver transplantation.
作者
贺希
刘鸿凌
HE Xi;LIU Hong-ling(Liver Transplantation Center, the Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China)
出处
《传染病信息》
2019年第3期274-277,共4页
Infectious Disease Information
基金
首都市民健康培养项目(Z161100000116058)
