不同剂量阿司匹林联合疏血通在改善老年急性脑梗死患者NIHSS评分和血液流变学指标中的作用

Effects of different doses of aspirin combined with Shuxuetong on improving NIHSS score and hemorheological indexes in elderly patients with acute cerebral infarction

目的探讨不同剂量阿司匹林联合疏血通在改善急性脑梗死患者NIHSS评分和血流变指标中的作用。方法选取2016年1月至2018年12月我院收治的急性脑梗死患者60例,按照随机数字表法将其分为试验组(n=30)和常规组(n=30)。常规组应用低剂量阿司匹林联合疏血通治疗,试验组应用高剂量阿司匹林联合疏血通治疗。比较两组患者的治疗效果。结果试验组治疗总有效率为96.67%,显著高于常规组的80.00%(P<0.05)。治疗后,两组患者NIHSS、mRS及Barthel指数评分均优于治疗前,且试验组优于常规组(P<0.05)。治疗后,两组患者全血高切黏度、全血低切黏度、血浆比黏度、血小板聚集率及CRP水平均低于治疗前(P<0.05);试验组血小板聚集率及CRP水平显著低于常规组(P<0.05)。两组患者不良反应总发生率无显著差异(P>0.05)。结论在老年急性脑梗死治疗中,应用200mg/d阿司匹林联合疏血通能够明显改善患者神经功能,抑制血小板聚集,减轻炎症反应,预防和减少血栓形成,患者预后更好,具有较高推广价值。

Objective To explore the effects of different doses of aspirin combined with Shuxuetong in improving NIHSS score and hemorheological indexes in patients with acute cerebral infarction. Methods A total of 60 patients with acute cerebral infarction admitted to our hospital from January 2016 to December 2018 were selected and divided into experimental group (n=30) and conventional group (n=30) according to random number table method. The conventional group was treated with low-dose aspirin combined with Shuxuetong, while the experimental group was treated with high-dose aspirin combined with Shuxuetong. The therapeutic effects of the two groups were compared. Results The total effective rate of treatment was 96.67% in the experimental group, which was significantly higher than 80.00% in the conventional group (P<0.05). After treatment, NIHSS, mRS and Barthel index scores of the two groups were better than those before treatment, and those in the experimental group were better than the conventional group (P<0.05). After treatment, the whole blood high shear viscosity, whole blood low shear viscosity, plasma specific viscosity, platelet aggregation rate and CRP levels in the two groups were lower than those before treatment (P<0.05);the platelet aggregation rate and CRP level in the experimental group were significantly lower than those in the conventional group (P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P>0.05). Conclusion The application of 200 mg/d aspirin combined with Shuxuetong in the treatment of elderly patients with acute cerebral infarction can significantly improve neurological function, inhibit platelet aggregation, alleviate inflammation, prevent and reduce thrombosis, with better prognosis of patients. It has high popularization value.