通心络胶囊联合氯吡格雷及阿司匹林在冠心病患者PCI术后的应用效果

Application effect of Tongxinluo capsule combined with clopidogrel and aspirin in patients with coronary heart disease after PCI

目的探究通心络胶囊联合氯吡格雷及阿司匹林在冠心病患者经皮冠状动脉介入(PCI)术后的应用效果。方法选取2010年11月至2013年11月我院收治的110例冠心病患者为研究对象,患者均行PCI术,依据随机数字表法将其分为对照组和试验组,各55例。对照组术前、术后均常规予以阿司匹林、氯吡格雷治疗,在此基础上,试验组术后予以通心络胶囊治疗。比较两组治疗前、后血液流变学指标水平、出血不良反应、心绞痛及再狭窄发生情况及生活质量评分。结果治疗4周后,试验组血浆比黏度、纤维蛋白原及全血比黏度均低于照组及治疗前(P<0.05)。试验组出血不良反应总发生率低于对照组(P<0.05)。试验组心绞痛发作及再狭窄发生率均显著低于对照组(P<0.05)。治疗12个月后,两组躯体功能、心理功能、社会功能及物质生活状态评分均显著升高,且试验组高于对照组(P<0.05)。结论通心络胶囊联合氯吡格雷及阿司匹林在冠心病患者PCI术后的应用效果显著,可有效降低出血反应、心绞痛及再狭窄发生率,改善患者血液流变学指标及生活质量,值得临床推广。

Objective To investigate the application effect of Tongxinluo capsule combined with clopidogrel and aspirin in patients with coronary heart disease after percutaneous coronary intervention (PCI). Methods A total of 110 patients with coronary heart disease admitted in our hospital from November 2010 to November 2013 were selected as the research objects and all underwent PCI. The patients were divided into control group and experimental group according to random number table method, with 55 cases in each group. The control group was treated with aspirin and clopidogrel before and after operation, on this basis, the experimental group was treated with Tongxinluo capsule after operation. The hemorheological indexes, incidences of bleeding adverse reaction, angina pectoris and restenosis and scores of life quality were compared between the two groups before and after treatment. Results After 4 weeks of treatment, the plasma specific viscosity, fibrinogen and whole blood specific viscosity of the experimental group were lower than those of the control group and before treatment (P<0.05).The total incidence of bleeding adverse reactions in the experimental group was lower than that in the control group(P<0.05). The incidences of angina attack and restenosis in the experimental group were significantly lower than those in the control group (P<0.05). After 12 months of treatment, the scores of physical function, psychological function, social function and material life state of the two groups increased significantly, and those in the experimental group were higher than the control group (P<0.05). Conclusion Tongxinluo capsule combined with clopidogrel and aspirin applied in patients with coronary heart disease after PCI has a significant effect, it can effectively reduce the incidence of hemorrhagic reaction, angina pectoris and restenosis, improve hemorheological indexes and quality of life of patients, which is worthy of clinical promotion.