角膜的年龄相关变化

Age-related changes of cornea

随着年龄的增长,人体的各个器官都经历着生长、发育乃至衰退的过程,眼球的各个组织也会出现相应的变化。角膜是构成眼表屏障和屈光系统的重要组成部分,它的生理状态及病理变化对疾病的诊断及治疗息息相关。随着年龄增长,角膜内皮细胞、神经纤维减少,角膜知觉减退,角膜密度值增加,角膜缘细胞群增生活力下降,高阶像差增大,生物力学值降低。研究角膜的年龄相关性变化,对于了解角膜病变的发生、发展规律,设计有效、个性的治疗方案,观察治疗效果,制定合理干预措施都是必要的。

With the growth of age, all organs of the human body are experiencing the process of growth, development and decline, and the various tissues of the eyeball will change accordingly. Cornea is an important component of ocular surface barrier and refractive system. Its physiological state and pathologi-cal changes are closely related to the diagnosis and treatment of diseases. With the growth of age, corneal endothelial cells and nerve fibers decrease, corneal hypoesthesia, corneal density increases, proliferation ac-tivity of limbal cell population decreased, higher order aberrations increase, and biomechanical value decrea-ses. It is necessary to study the age-related changes of cornea for understanding the occurrence and develop-ment of corneal diseases, designing effective and personalized treatment programs, observing the therapeutic effect, and formulating reasonable intervention measures.