洛阳地区415例男性不育症患者染色体核型及Y染色体微缺失分析

Analysis of chromosome karyotype and Y chromosome microdeletion in 415 patients with male infertility in Luoyang area

目的通过对洛阳地区男性不育症患者的染色体核型及Y染色微缺失情况的分析,为患者的生育提供指导。方法对来就诊的临床诊断为男性不育症的415例患者,进行染色体核型分析和Y染色体微缺失检测。结果 415例不育症患者中,染色体核型异常率为12.29%(51/415),最常见类型为47,XXY,占35.29%(18/51)。Y染色体微缺失发生率为10.12%(42/415),最常见类型为仅AZFc区域缺失,占57.14%(24/42)。结论染色体核型与Y染色体微缺失的检测,为男性不育症患者明确病因以及进一步的临床治疗提供了科学依据。

Objective:To investigate chromosome karyotypes and Y chromosome microdeletions in patients with male infertility in Luoyang area,in order to provide guidance for the fertility of the patients. Methods:Chromosome karyotype analysis and Y chromosome microdeletion analysis were performed in 415 male infertility patients who were diagnosed as male infertility.Results:Among 415 infertility patients,the chromosomal karyotype abnormality rate was 12.29%(51/415),the most common type was 47,XXY,accounting for 35.29%(18/51). The incidence rate of Y chromosome microdeletion was 10.12%(42/415),and the most common type was only AZFc region deletion,accounting for 57.14%(24/42). Conclusion:The detection of chromosome karyotype and Y chromosome microdeletion provides scientific basis for the identification of etiology and further clinical treatment of male infertility.