不同妊娠期血清维生素A和维生素E水平及相关性分析

Analysis of serum vitamin A and vitamin E levels and correlations in different gestational periods

目的分析不同妊娠期血清维生素A、E含量以及不同妊娠期维生素A、E缺乏或者过量等主要异常表现及其相关性。方法采集整理2015年10月到2017年10月在北京航天总医院进行常规围产保健的妊娠女性1421例,利用高效液相色谱法检测不同妊娠期血清维生素A、E的质量浓度,并定量分析其水平、异常率以及相关性等统计信息。结果妊娠早、中、晚期血清维生素A、E含量的频率分布均表现为近似正态分布;妊娠早、中、晚期血清维生素A、E含量分别为(0.45±0.09)mg/L、(0.45±0.10)mg/L、(0.40±0.09)mg/L,及(10.95±2.50)mg/L、(14.94±3.12)mg/L、(16.82±3.71)mg/L;经方差分析F值分别为122.3和1288,P值均小于0.05;妊娠早、中、晚期血清维生素A、E含量的缺乏比率分别为2.96%、3.66%、11.96%,以及0.07%、0.00%、0.00%,过量比率分别为1.06%、1.55%、0.42%,以及0.63%、6.33%、18.30%;妊娠中期和晚期血清维生素A、E含量的Pearson相关系数达到最大,其值分别为0.68、0.70,P值均小于0.05。结论妊娠期血清维生素A异常主要表现为晚期缺乏,维生素E异常主要表现为晚期过量,妊娠中期和晚期维生素A、E含量的相关性更强,应当根据女性不同妊娠期维生素A、E的异常表现,分别采取针对性干预。

Objective:Investigate the comprehensive status of serum vitamin A and E levels in different gestational periods,as well as the main abnormalities and correlations of vitamin A and E deficiency or excess during different gestation periods,to scientifically adjust the vitamin A and E contents of pregnant women and provide important reference for interventions in advance,and improve the quality of perinatal care. Methods:A total of 1421 pregnant women who underwent routine perinatal care at Beijing Aerospace General Hospital from October 2015 to October 2017 were enrolled. The mass concentration of serum vitamins A and E in different gestational periods were measured by high performance liquid chromatography(HPLC). Statistical information such as level,abnormal rate,and correlation was analyzed. Results:The level of serum vitamin A and E in early,middle and late pregnancy were(0.45±0.09)mg/L,(0.45 mg±0.10)/L,(0.40±0.09)mg/L,and(10.95±2.50)mg/L,(14.94±3.12)mg/L,(16.82±3.71)mg/L,respectively;The F values of variance analysis were 122.3 and 1288,respectively,and the P values were less than 0.05;the frequency distribution of serum vitamin A and E in early,middle and late pregnancy all showed an approximate normal distribution;the deficiency ratios of serum vitamin A and E in early,middle and late pregnancy were 2.96%,3.66%,11.96%,and 0.07%,0.00%,0.00%,respectively,excess ratios were 1.06%,1.55%,0.42%,and 0.63%,6.33%,18.30%,respectively;The Pearson correlation coefficients between serum vitamin A and E in middle and late pregnancy both reached the maximum,with the values of 0.68 and 0.70,respectively,and the P values were less than 0.05. Conclusion:The abnormality of serum vitamin A mainly performs as deficiency in late pregnancy. The abnormality of vitamin E mainly performs as excess in late pregnancy. The correlation between vitamin A and E in middle and late pregnancy is stronger. According to this,on the basis of the abnormal performance of vitamin A and E in different pregnancy stages of women in clinical practice,targeted detection and intervention measures can be taken to achieve the purpose of prevention in advance.