摘要
IgA肾病是全球范围内导致终末期肾脏病(ESRD)的主要病因之一,20%~40%的IgA肾病患者在确诊20年内进展至ESRD。因此,探索促进IgA肾病进展的危险因素,提高评估疾病进展情况和预测疾病预后的准确性,具有重要的临床意义。本综述从IgA肾病的临床-病理表现、免疫-补体机制、氧化应激-炎症因子以及microRNA-易感基因方面概括近年来研究的促进疾病进展的危险因素。
IgA nephropathy(IgAN)is one of the leading causes of end-stage renal disease(ESRD),and 20%-40%of IgAN patients progress to ESRD in 20 years.Therefore,it is of great significance to explore the risk factors for IgAN progression,which can improve the accuracy of assessment of disease progression and prediction of prognosis.This review summarizes the risk factors for IgAN progression that have been studied in recent years from the aspects of clinicopathological manifestations,immune-complement mechanisms,oxidative stress-inflammatory cytokines and microRNA-susceptibility genes.
作者
唐红娟
熊重祥
邹和群
TANG Hong-juan;XIONG Chong-xiang;ZOU He-qun(Department of Nephrology,the Third Affiliated Hospital of Southern Medical University,Guangzhou 510000,China)
出处
《实用临床医学（江西）》
CAS
2019年第5期92-96,共5页
Practical Clinical Medicine
基金
广州市科技计划项目(201510162027570)
