肺腺癌中RNPC1蛋白、EGFRv Ⅲ蛋白表达水平及意义

Expression and significance of RNPC1 protein and EGFRv Ⅲ protein in lung adenocarcinoma

目的探讨肺腺癌中RNPC1蛋白、EGFRvⅢ蛋白表达水平及意义。方法选取2015年1月至2018年4月我院保存的肺腺癌组织标本89例,同时选取癌旁组织作为对照组,采用Western blot检测RNPC1蛋白、EGFRvⅢ蛋白表达。结果肺腺癌组织RNPC1和EGFRvⅢ蛋白相对表达量分别为(0.833±0.122)和(0.910±0.115),明显高于癌旁组织(P<0.05);肺腺癌Ⅲ期、有淋巴结转移患者RNPC1蛋白相对表达量分别为(0.892±0.115)和(0.898±0.120),明显高于Ⅰ~Ⅱ期、无淋巴结转移患者(P<0.05);肺腺癌女性、中低分化患者EGFRvⅢ蛋白相对表达量分别为(0.960±0.139)和(0.933±0.112),明显高于男性、高分化患者(P<0.05)。结论肺腺癌中RNPC1蛋白、EGFRvⅢ蛋白表达明显升高,与临床病理特征有一定关系,值得进一步研究。

Objective To investigate the expression and significance of RNPC1 protein and EGFRvⅢprotein in lung adenocarcinoma.Methods 89 lung adenocarcinoma specimens from January 2015 to April 2018 were selected,and the para cancerous tissue were selected as the control group.Western blot was used to detect the expression of RNPC1 protein and EGFRv III protein.Results The relative expression of RNPC1 and EGFRvⅢprotein in lung adenocarcinoma tissue were(0.833±0.122)and(0.910±0.115),which were significantly higher than that of para cancerous tissue(P<0.05).The relative expression of RNPC1 protein in patients with stageⅢof lung adenocarcinoma and lymph node metastasis were(0.892±0.115)and(0.898±0.120),which were significantly higher than that in stageⅠtoⅡand no lymph node metastases(P<0.05).The relative expression of EGFRvⅢprotein in female,middle and low differentiation were(0.960±0.139)and(0.933±0.112),which were significantly higher than that in male and high differentiated patients(P<0.05).Conclusion The expression of RNPC1 protein and EGFRvⅢprotein in lung adenocarcinoma are increased significantly,which are related to clinicopathological features,and is worthy of further study.