穴位贴敷联合常规抗结核化疗药物治疗复治肺结核的效果及对患者免疫功能的影响

Clinical effect of acupoint application combined with conventional anti 一 tuberculosis treatment on pulmonary tuberculosis and its influence on the immune function

目的探究穴位贴敷联合常规抗结核治疗复治肺结核的效果及对患者免疫功能的影响,方法选取2016年3月至2017年9月杭州市红十字会医院收治的复治肺结核患者64例为研究对象,采用随机数字表法分成只采用常规抗结核化疗药物的对照组(n=30)和常规治疗联合穴位贴敷的观察组(n =34)。比较两组临床疗效、肺功能、免疫功能。结果对照组吸收率为46.67%,明显低于观察组的76.47%(x^2=6.04,P<0.05);两组患者治疗后同治疗前比较,用力肺活量(FVC)、一秒用力呼气容积(FEV,)以及FVC/FEV,均显著提高,两组治疗后比较,观察组FVC .FEV,以及FVC/FEV,水平分别为(2.20 ±0.48) L、( 2.50 ±0.34) L、(87.44 ± 13.60)%,均显著高于对照组的(1.63 ± 0.32) L、(2.02 ±0.44) L、( 80.28 ± 12.66)%(t = 6.607,5.687 ,2.558,均 P<0.05);观察组患者治疗后同治疗前比较,CD3、CD4、CD8、CD4/CD8,IgC、IgA、IgM 都有显著提高(均P < 0.05 ),两组治疗后比较,观察组CD3、CD4、CD8、CD4/CD8,IgC、IgA、IgM水平分别为(73.25 +6.17)%、(38.65 ±5.75)%、(36.58 ±3.17)%、( 1.52 ±0.65)、( 15.49 ± 1.49)g/L、(3.07 ± 1.30) g/L、(1.94 ±0.50)g/L,均显著高于对照组的(68.43 ±6.4)%、(34.72 ±5.68)%、(35.02 ±3.08)%、(1.16 ±0.78),(12.61 ± 1.64)g/L、(2.23 ±0.90)g/L、( 1.68 ±0.35)g/L(t = 3.590,3.223 >2.340,2.340,8.594、3.550、2.846.均P <0.05);结论穴位贴敷与常规抗结核化疗药物联合治疗复治肺结核相比于常规抗结核化疗药物治疗效果更好,能够显著提高复治肺结核患者的免疫功能,提高复治肺结核治疗的成功率。

Objective To explore the effect of acupoint application combined with conventional anti-tuber-culosis treatment on pulmonary tuberculosis and its effect on the immune function of patients.Methods A total of 64 patients with pulmonary tuberculosis who visited Hangzhou Red Cross Hospital from March 2016 to September 2017 were selected in the study.The patients were randomly divided into control group(n=30)and observation group(n=34)according to the digital table.The clinical curative effect(obvious absorption,absorption,no change and deterioration),lung function(FVC,FEV1 and FVC/FEV1),immune function(CD+3,CD+4,CD+8,CD+4/CD+8,IgC,IgA,IgM)were compared between the two groups.Results The absorptive rate of the control group was 46.67%,which was significantly lower than that of the observation group(76.47%,χ2=6.04,P<0.05).After treat-ment,the levels of FVC,FEV1 and FVC/FEV1 of the two groups were significantly increased compared with before treatment..After treatment,the levels of FVC,FEV1 and FVC/FEV1 in the observation group were(2.20±0.48)L,(2.50±0.34)L,(87.44±13.60)%,respectively,which were significantly higher than those in the control group[(1.63±0.32)L,(2.02±0.44)L,(80.28±12.66)%](t=6.607,5.687,2.558,all P<0.05).After treat-ment,the CD+3,CD+4,CD+8,CD+4/CD+8,IgC,IgA,IgM levles in the observation group were significantly increased compared with before treatment(all P<0.05).After treatment,the CD+3,CD+4,CD+8,CD+4/CD+8,IgC,IgA,IgM levles in the observation group were(73.25±6.17)%,(38.65±5.75)%,(36.58±3.17)%,(1.52±0.65),(15.49±1.49)g/L,(3.07±1.30)g/L,(1.94±0.50)g/L,respectively,which were significantly higher than those in the control group[(68.43±6.4)%,(34.72±5.68)%,(35.02±3.08)%,(1.16±0.78),(12.61±1.64)g/L,(2.23±0.90)g/L,(1.68±0.35)g/L](t=3.590,3.223,2.340,2.340,8.594,3.550,2.846,all P<0.05).Conclusion Conventional anti-tuberculosis chemotherapy drugs combined with acupuncture has better effect than conventional anti-tuberculosis chemotherapy drugs.It can significantly improve the immune function of patients,improve the success rate of treatment,and speed up the improvement of the patients'condition.