兔尺骨中段临界节段性骨缺损模型的建立

Establishment of a critical segmental bone defect model in a rabbit ulna

目的建立一种兔尺骨的节段性骨缺损模型。方法选择20只雄性新西兰大白兔,采用随机数字表法分为五组,分别于双侧尺骨中段制作14 mm、15 mm、16 mm、17 mm、18 mm的节段性骨缺损,切除骨质包含骨膜,术后6周、12周通过大体观察、影像学观察及组织学观察评价节段性骨缺损修复情况。结果术后12周14 mm 、15 mm组节段性骨缺损完全修复,16 mm、17 mm、18 mm组节段性骨缺损未见修复。结论16 mm是兔尺骨中段节段性骨缺损的临界长度。

Objective To establish a critical segmental bone defect model in a rabbit ulna.Methods Twenty male New Zealand white rabbits were randomly assigned into 5 groups according to the digital table,and then 14,15,16,17 and 18mm segmental defects (contained periosteum) were created in the middle part of ulna on both sides,respectively.At 6 and 12 weeks after surgery,the repair of segmental bone defects was evaluated by na ked eyes,X-ray and histological examination.Results At 12 weeks after surgery,all of the segmental defects with the length of 14 and 15mm were completely repaired.But none of the defects with the length of 16,17 and 18mm was repaired.Conclusion The length of critical segmental bone defect in rabbit ulna was 16 mm.