长链非编码RNA在病毒与宿主相互作用中功能的研究进展

Advances in research on the function of long non-coding RNA in virus-host interaction

长链非编码RNA(long non-coding RNA,IncRNA)在细胞生命活动中扮演着重要的角色,在病毒与宿主相互作用中也发挥多种调控作用。病毒的感染能诱导细胞内多种IncRNA的差异表达,而差异表达的IncRNA又可通过各种方式来对侵染的病毒起到或抑制或协助的作用。本文主要列举了不同种类的病毒所诱导的差异表达的IncRNA,以及病毒与这些IncRNA之间的相互作用机制。

Long non-coding RNAs ( IncRNAs) play important roles in several cellular biogenic activities, including the virus-host interaction as well. Virus infection could induce aberrant expression of multiple IncRNAs, and some of these IncRNAs could facilitate or suppress the virus infection via diverse mechanisms. In this paper, we enumerate the differentially expressed IncRNAs induced by different types of viruses and summarize the potential mechanism of interaction between viruses and these IncRNAs.