betatrophin在阻塞性睡眠呼吸暂停低通气综合征患者血浆中的水平及临床意义

Plasma levels of betatrophin in patients with obstructive sleep apnea hypopnea syndrome and its clinical significance

目的探讨betatrophin在阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血浆中的水平及临床意义。方法选取2016年1月~2017年12月在我院睡眠中心行多道睡眠图(PSG)监测患者90例,分为非OSAHS组29例、轻中度OSAHS组31例和重度OSAHS组30例。采用酶联免疫吸附试验检测血清中betatrophin水平。用Logistics回归分析探讨OSAHS的影响因素。结果轻中度OSAHS组和重度OSAHS组患者年龄、体质量指数(BMI)、颈围、腰臀比(waist-to-hip ratio,WHR)、呼吸暂停低通气指数(AHI)、最低指脉氧饱和度(lowest SpO2,LSpO2)、氧减指数(oxygen desaturation index,ODI)、氧饱和度低于90%的时间占睡眠的百分比(the percent of time spent below90%oxygensaturation,Ts90%)、TG和betatrophin高于非OSAHS组,差异有统计学意义(P <0.05);重度OSAHS组患者年龄、BMI、颈围、WHR、AHI、LSpO2、ODI、Ts90%、甘油三酯(triglycerides,TG)和betatrophin高于轻中度OSAHS组,差异有统计学意义(P <0.05)。剔除混杂因素的影响校正后,血清betatrophin水平与性别呈独立负相关,与BMI、WHR、ODI和血脂异常呈独立正相关(β=-0.342、0.438、0.639、0.185、0.336,P均<0.05);年龄、BMI、W HR和betat rophin是OSAHS患者评估的独立危险因素(OR=1.259、1.706、3.315、1.226,P均<0.05)。结论血清betatrophin是OSAHS患者评估的独立危险因素,可为预测OSAHS提供线索。

OBJECTIVE To investigate the plasma level of betatrophin in patients with obstructive sleep apnea hypopnea syndrome(OSAHS) and its clinical significance. METHODS A total of 90 patients underwent polysomnograghy(PSG) in our hospital from January 2016 to December 2017 were selected and divided into three groups: non-OSAHS group(n=29), mild-moderate OSAHS group(n=31), and severe OSAHS group(n=30). Enzymelinked immunosorbent assay was used to detect the serum level of betatrophin. Logistic regression analysis was used to explore the inf luencing factors of OSAHS. RESULTS The age, BMI, neck circumference, WHR, AHI, LSpO2,ODI, Ts90%, TG and betatrophin in the mild-moderate OSAHS group and severe OSAHS group were higher than those in non-OSAHS group(P <0.05). The age, BMI, neck circumference, WHR, AHI, LSpO2, ODI, Ts90%, TG and betatrophin in the severe OSAHS group were higher than those in mild-moderate OSAHS group(P <0.05). After correcting for the confounding factors, serum betatrophin level was negatively correlated with gender, and positively correlated with BMI, WHR, ODI and dyslipidemia(β=-0.342, 0.438, 0.639, 0.185, 0.336, P <0.05). The age,BMI, WHR and betatrophin were independent risk factors for OSAHS patients(OR=1.259, 1.706, 3.315, 1.226, P <0.05).CONCLUSION Serum betatrophin is an independent risk factor for OSAHS patients, which can be used as a predictor.