白细胞介素33与支气管哮喘的研究进展

Research advances on IL-33 and bronchial asthma

白细胞介素33 (IL-33)是IL-1家族的成员,是Th2免疫反应及变态反应性气道疾病重要的细胞因子。IL-33在肺组织上皮高表达,在黏膜器官的固有免疫和获得性免疫中起着重要作用。IL-33促进变应原特异性Th2型免疫应答,激活了多种与哮喘发病机制相关的细胞(如肥大细胞、嗜碱粒细胞、嗜酸粒细胞等)。越来越多的证据表明,IL-33通过诱导Th2型免疫反应,在哮喘的发病机制中起着重要作用。本文就IL-33结构、生物学活性及其在哮喘发病机制中的作用作一综述。

Interleukin 33 (IL-33) is a member of the IL-1 cytokine family, which is a key cytokine involved in Th2-type inflammatory responses and allergic airway diseases.Abundantly expressed in lung epithelial cells,IL-33 plays critical roles in both innate and adaptive immune responses in mucosal organs.IL-33 promotes allergen specific Th2 immune response and activates various cell types involved in asthma pathogenesis (mast cells, basophils, eosinophils, etc).Increasing evidence indicates that IL-33 plays an important role in the pathogenesis of asthma,mainly by inducing Th2 immune responses.In this article,we reviewed IL-33 from its molecular structure,bioactivities and its role in the pathogenesis of asthma.