基于处方数据分析中医药治疗肝硬化腹水的用药规律

Analysis of the Rule of Medication for Treating Liver Cirrhosis with Ascites Based on Prescription Data

目的基于数据库挖掘中医药治疗肝硬化腹水组方规律。方法从中国知网(CNKI)、百度学术、维普中文期刊数据库(VIP)、万方医学数据库、PubMed数据库收集关于中医药治疗肝硬化腹水的文献中处方,利用Excel2007构建数据集并规范中药命名,录入中医传承辅助平台软件(TCMISSV2.5)进行数据分析,以获得中医药治疗肝硬化腹水用药规律。结果共纳入201首处方,使用频次≥16次的中药有64味,以补益药、利水渗湿药、活血化瘀药、理气药为主,性味以寒、温、平,甘、苦、辛为主,主要归肝、脾、胃、肺经,获得强药物关联模式83条,常用药对102对,通过熵层次聚类分析得到13个候选新方。结论近代医家治疗肝硬化腹水以“攻补兼施”为治则,治法上注重健脾益气、利水渗湿、活血化瘀,并辅以宣肺解表、清热理气、消食化滞之法。

Objective Based on database mining Chinese medicine for the treatment of cirrhosis and ascites,and to discover new prescriptions.Methods From the China Knowledge Network,Baidu Academic,Weipu Chinese Journal Database,Wanfang Medical Database,PubMed database to collect prescriptions on the treatment of cirrhosis ascites in Chinese medicine,using Excel2007 to build data sets and standardize Chinese medicine naming,enter the Chinese medicine inheritance platform The software(TCMISS V2.5)was used for data analysis to obtain the rule of traditional Chinese medicine for treating cirrhosis and ascites.Results A total of 201 prescriptions were included.The traditional Chinese medicine with frequency≥16 times has 64 flavors.It is mainly used for replenishing medicine,water-sparing osmotic medicine,promoting blood circulation and removing phlegm medicine,and qi medicine.The taste is cold,warm,flat,sweet and bitter.Mainly due to sin,mainly to the liver,spleen,stomach,lung,83 strong drug association patterns,102 pairs of commonly used drugs,13 candidate new parties by entropy hierarchical cluster analysis.Conclusion Modern medical doctors treat cirrhosis ascites with“over-the-counter and application”as the rule of cure.The treatment focuses on spleen-reinforcing qi,dilute water and phlegm,promoting blood circulation and removing blood stasis,supplemented by Xuanfei solution,clearing heat and qi,digestion and stagnation.The law.