伴神经内分泌分化胃癌远处转移危险因素分析

Risk factors of distant metastasis in patients with gastric cancer accompanying neuroendocrine cell differentiation

目的分析伴神经内分泌分化(neuroendocrine cell differentiation, NED)胃癌发生远处转移的相关危险因素。方法回顾性分析71例复旦大学附属华山医院于2007年1月—2018年8月期间行手术根治且病理确诊为伴神经内分泌分化胃癌患者的临床、病理及术后随访资料,分析其与肿瘤远处转移的相关性。结果单因素及多因素Cox回归分析示肿瘤浸润深度(≥T3)、淋巴结转移数(≥4枚)、术中出血量(≥300 mL)是肿瘤远处转移的独立影响因素( P <0.05)。结论原发肿瘤浸润深度、区域淋巴结转移、术中出血量是影响胃癌伴NED患者远处转移的相关因素。

Objective To analyze the risk factors of distant metastasis in patients with gastric cancer accompanying neuroendocrine cell differentiation (NED). Methods Clinicopathological data of 71 gastric cancer patients with NED who received gastrectomy in Huashan Hospital Fudan University from January 2007 to August 2018 were reviewed retrospectively. The risk factors of distant metastasis were analyzed with univariate and multivariate regression. Results Univariate and multivariate analysis showed that infiltration depth ≥T3, lymph nodes metastasis ≥4 and intraoperative bleeding volume≥300 mL were independent positive factors of distant metastasis ( P <0.05). Conclusion Tumor infiltration depth, the number of lymph nodes metastasis and the volume of intraoperative bleeding may increase the risk of distant metastasis of gastric cancer accompanying NED.