TyG指数与体检人群非酒精性脂肪性肝病相关性分析

Correlation relationship between triglyceride-glucose index and nonalcoholic fatty liver disease in health checkup polulation

目的分析探讨空腹三酰甘油葡萄糖乘积(triglyceride-glucoseindex,TyG)与非酒精性脂肪性肝病(nonalcoholicfattyliverdisease,NAFLD)的相关性。方法选取2016年1月1日~12月31日在解放军联勤保障部队第九八○医院(白求恩国际和平医院)健康管理中心参加健康体检且符合纳入及排除标准者8215名,分析其人口学特征,计算NAFLD的总检出率,比较不同TyG组相关代谢性指标的水平,NAFLD组与无NAFLD组相关代谢性指标的水平,同时行TyG水平与各项指标的相关性分析,及NAFLD发病相关因素的logistic回归分析。结果8215名年龄中位数(M)为43岁,四分位数间距(QR)为18岁;NAFLD的总检出率为33.37%(2741/8215)。按四分位数将TyG指数分为Q1、Q2、Q3、Q44组,年龄、血清总胆固醇(TC)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、尿酸(UA)、体重指数(BMI)、腰高比(WSR)各组间比较差异均有统计学意义(P<0.001);NAFLD组较无NAFLD组的年龄、空腹血糖(FPG)、TC、三酰甘油(TG)、LDL-C、UA、TyG、BMI、WSR均升高,而HDL-C降低,差异有统计学意义(P<0.001)。logistic回归分析提示TyG、TG、FPG、UA、BMI、WSR为NAFLD的危险因素(P<0.05);Spearman相关分析TyG水平与年龄、BMI、WSR、FPG、TC、TG、LDL-C、UA呈正相关(P<0.001),与HDL-C呈负相关(P<0.001)。TyG在ROC曲线下面积为0.805。结论TyG与NAFLD及异常代谢性指标关系密切,TyG是提示NAFLD存在的一项简便易行的生物学指标。

Objective To investigate the relationship between triglyceride-glucose index(TyG) and nonalcoholic fatty liver disease(NAFLD) in checkup population. Methods A total of 8215 healthy people who underwent health checkup form January 1 to December 31,2016 were recruited in this study,according to inclusion and exclusion standard. The demographic characteristics and detection condition of NAFLD were analyzed,indicators between different TyG groups,NAFLD group and non-NAFLD group were observed and compared. Meanwhile,the correlation between TyG and various indicators was analyzed,and logistic regression analysis was used to analyze the correlation of NAFLD to related factors. Results The median age of the 8215 healthy people was 43 years old and the interquartile distance was 18 years. The total detection rate of NAFLD was 33.37%;the TyG index was divided into four groups by four digits: Q1,Q2,Q3 and Q4. There were significant differences in age,serum total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),uric acid(UA),body mass index(BMI) and waist-to-stature ratio(WSR) among groups. Compared with those in non-NAFLD group,age,fasting plasma glucose(FPG)、TC、triglyceride(TG)、LDL-C、UA、TyG、BMI and WSR were significantly increased in NAFLD group,while values of high density lipoprotein cholesterol(HDL-C) level was decreased(P < 0.001);Logistic regression analysis showed that TyG、TG、FPG、UA、BMI and WSR were risk factors for NAFLD(P < 0.05). Spearman's correlation analyses showed a positive correlation between TyG and age,BMI、WSR、FPG、TC、TG、LDL-C 、UA and negative correlation between HDL-C. The area under the ROC curve was 0.805. Conclusion TyG is closely related to NAFLD and dyslipidemias,which is a simple biological indicator for the diagnose of NAFLD.