厄洛替尼联合放射治疗食管癌的Meta分析

Meta Analysis of Erlotinib Combined with Radiotherapy for Esophageal Cancer

目的系统评价厄洛替尼联合放疗与单纯放疗治疗食管癌的总有效率及皮疹、消化系统反应发生率。方法检索知网、万方、维普中文科技期刊数据库等有关厄洛替尼联合放疗治疗食管癌的随机对照试验(RCT),搜索截止至2017年4月。按照纳入及排除标准筛选文献,使用RevMan5.3软件对数据进行统计学评价。结果共纳入6篇RCT,631例食管癌患者。统计结果表明观察组治疗总有效率显著高于对照组,皮疹发生率和消化系统反应发生率显著低于对照组,差异均有统计学意义。结论厄洛替尼联合放疗较单纯放疗提高了治疗总有效率,而皮疹及消化系统反应均有所降低。

Objective To systematically evaluate erlotinib combined with radiotherapy compared with radiotherapy alone in the treatment of ,the total incidence rate of esophageal carcinoma reaction efficiency rate of rash and digestive system. Method A ran? domized controlled trial of erlotinib retrieval CNKI,Wanfang,VIP Chinese science and technology periodical database imatinib com? bined with radiotherapy for esophageal cancer(RCT)was done,and the deadline was April,2017. The literature was screened accord? ing to inclusion and exclusion criteria,and the data were statistically evaluated through using RevMan 5.3 software. Results A total of 6 RCT and 631 patients with esophageal cancer were enrolled. The statistical results showed that the total effective rate of the observa? tion group was significantly higher than that of the control group,and the incidence of skin rash and digestive system reaction was sig? nificantly lower than the control group. The difference was statistically significant. Conclusion Erlotinib combined with radiotherapy compared with radiotherapy alone improves the treatment efficiency,and the reaction was rash and digestive system decreased.