探讨分析血清D-二聚体、同型半胱氨酸(Hcy)与急性脑梗死的相关性及临床意义

To Investigate the Correlation and Clinical Significance of Serum D-Dimer, Homocysteine(Hcy) and Acute Cerebral Infarction

目的探究与分析血清D-二聚体及同型半胱氨酸与急性脑梗死的相关性及其临床意义。方法在2017年8月-2018年12月时间段内于该院接受诊治的急性脑梗死患者80例为观察组;在同一时间段内于该院接受健康体检的80名为对照组。对两组患者进行血清D-二聚体及同型半胱氨酸指标的检测,将两组患者的检测结果予以对比。结果观察组患者的血清D-二聚体及同型半胱氨酸水平指标结果显著低于对照组患者,急性脑梗死患者的此两项指标结果[(537.2±201.3)μm/L、(22.9±6.7)μmol/L]均高于健康体检者[(159.4±198.7)μm/L、(11.4±6.5)μmol/L],两组之间的差异有统计学意义(t=8.087、5.021,P<0.05)。且在观察组中,重度、中度及轻度急性脑梗死患者的血清D-二聚体及同型半胱氨酸指标指标结果相较均有显著性差异(P<0.05),急性脑梗死患者的病情程度与血清D-二聚体及同型半胱氨酸两项指标结果呈现正相关的关系。结论血清D-二聚体及同型半胱氨酸(Hcy)指标对急性脑梗死的发生及发展具有重大的相关性,此两项指标的联合检测对于急性脑梗死的早期诊断及相关的病情严重程度判断具有十分重大的意义,在临床的应用应该引起足够的重视。

Objective To investigate and analyze the relationship between serum D-dimer and homocysteine and acute cerebral infarction and its clinical significance. Methods Eighty patients with acute cerebral infarction who were treated in our hospital from August 2017 to December 2018 were included in the observation group. Eighty patients who received a physical examination in our hospital during the same period of time were included in the control group. Serum D-dimer and homocysteine levels were measured in both groups, and the results of the two groups were compared. Results The serum D-dimer and homocysteine levels in the observation group were significantly lower than those in the control group. The results of these two indexes in patients with acute cerebral infarction [(537.2±201.3)μm/L,(22.9±6.7)μmol/L] were higher than those in healthy subjects [(159.4±198.7)μm/L,(11.4±6.5)μmol/L]. The difference between the two groups was statistically significant (t=8.087, 5.021, P<0.05). In the observation group, the serum D-dimer and homocysteine index of patients with severe, moderate and mild acute cerebral infarction were significantly different (P<0.05). The degree of disease in patients with acute cerebral infarction was positively correlated with the results of serum D-dimer and homocysteine. Conclusion Serum D-dimer and homocysteine (Hcy) indicators have a significant correlation with the occurrence and development of acute cerebral infarction. The combined detection of these two indicators is of great significance for the early diagnosis of acute cerebral infarction and the severity of the relevant disease, and should be paid enough attention in clinical application.