美金刚联合盐酸多奈哌齐治疗阿尔茨海默症患者疗效观察

Clinical Effect of Memantine Combined with Donepezil on Cognitive Function and Mental Symptoms in Patients with Alzheimer’s Disease

目的:探讨美金刚联合盐酸多奈哌齐对阿尔茨海默患者认知功能与精神症状的临床疗效。方法:选择阿尔茨海默症患者101例,随机分为观察组(n=51)和对照组(n=50)。对照组采用盐酸多奈哌齐治疗,观察组在对照组基础上联合美金刚治疗,比较2组患者治疗12周后的总有效率与治疗前后的简易智能状态量表(MMSE)评分、阿尔茨海默症行为病理评定量表(BEHAVE-AD)评分。结果:观察组治疗12周后总有效率(96.08%)高于对照组(78.00%)(P<0.05);治疗12周后,2组患者MMSE评分比治疗前高,且观察组MMSE评分[(26.42±2.98)分]高于对照组[(22.42±1.12)分](P<0.05);治疗12周后,2组患者BEHAVE-AD评分比治疗前低,且观察组的BEHAVE-AD评分[(3.42±1.58)分]比对照组[(5.42±0.32)分]低(P<0.05)。结论:美金刚联合盐酸多奈哌齐治疗阿尔茨海默症的临床效果显著,能有效改善患者认知功能与精神症状。

Objective:To investigate the clinical effect of memantine combined with donepezil on cognitive function and mental symptoms in patients with Alzheimer’s disease (AD). Methods: 101 patients with AD treated were divided into observation group (51 cases) and control group (50 cases) by random number table. The control group took donepezil,and the observation group was treated with memantine on the basis of the control group. The total effective rate after treatment for 12 weeks,mini-mental state examination (MMSE),rating scale of the behavioral pathology in Alzheimer’s disease (BEHAVE-AD) before and after treatment were compared between two groups. Results: Compared with the control group (78.00%),the total effective rate of the observation group (96.08%) after treatment for 12 weeks was higher ( P <0.05);After treatment for 12 weeks,the MMSE scores of two groups were higher than those before treatment,and the MMSE score in observation group [(26.42±2.98)points] was higher than that in control group [(22.42±1.12)points]( P <0.05);After treatment for 12 weeks,the scores of BEHAVE-AD in two groups were lower than those before treatment,and the score of BEHAVE-AD in observation group [(3.42±1.58)points] was lower than that in control group [(5.42±0.32)points]( P <0.05). Conclusion: Memantine combined with donepezil in treatment of AD has significant clinical effects,which can effectively improve the cognitive function and mental symptoms of patients.