运动干预对抑郁障碍患者疗效及生活质量的影响

Effect of exercise intervention on symptomatic improvement and quality of life in patients with depression

目的探讨运动干预对抑郁障碍患者疗效及生活质量的影响。方法选取96例抑郁障碍患者随机分为观察组和对照组,2组患者均接受常规抗抑郁药物治疗、健康教育,同时对观察组实施为期6周的运动干预,在基线和第6周分别采用汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)、36条目简明量表(SF-36)进行评定。结果观察组入组48例,13例运动不达标、35例运动达标,将达标35例纳入研究。对照组入组48例,脱落9例、完成39例,将完成39例纳入研究。治疗后,2组患者的HAMD、HAMA评分均比治疗前降低(P均<0.05),其中观察组抑郁障碍患者的HAMD、HAMA评分均低于对照组(P均<0.05)。治疗后,观察组SF-36的生理机能、生理职能、一般健康、精力、社会功能、情感职能评分均高于对照组(P均<0.05)。结论对抑郁障碍患者给予运动干预,可以改善其抑郁、焦虑情绪,提高患者生活质量。

Objective To evaluate the effect of exercise intervention on the symptomatic improvement and quality of life in patients with depression. Methods A total of 96 patients diagnosed with depression were enrolled and randomly divided into the study( n = 48) and control groups( n = 48). All patients in both groups received conventional ant-depressant medication and health education. Besides, patients in the study group were prescribed with a 6-week exercise intervention program. Hamilton Scale( HAMD-17), Hamilton Anxiety Scale( HAMA) and the Short Form-36 health survey( SF-36) were assessed at the baseline and 6 weeks. Results In the study group, 13 patients failed to complete the exercise intervention and 35 completed the exercise intervention. These 35 patients were eligible for subsequent study. In the control group, 9 patients were lost and 39 completed the treatment. These 39 cases were included for subsequent investigation. After corresponding treatment, the HAMD-17 and HAMA scores were significantly lower compared with those before treatment in two groups( both P < 0.05). The HAMD-17 and HAMA scores in the study group were significantly lower than those in the control group( both P < 0.05). After corresponding treatment, the scores of different dimensions of SF-36 including physical function( PF), physical role( RP), general health( GH), vitality( VT), social function( SF) and emotional role( RE) in the study group were significantly higher compared with those in the control group( all P < 0.05). Conclusion Exercise intervention can mitigate the depression and anxiety symptoms and enhance quality of life in patients with depression.