摘要
目的 评价乌司他丁对紫绀小儿心脏手术围术期的肺保护作用的影响,并进行术后7年随访。方法 本研究为回顾性队列研究。选取本院于2010年1月至12月接受法洛四联症(TOF)矫治术的单纯TOF患儿184例。根据术中是否应用乌司他丁被分为两组:对照组(n=77)和乌司他丁组(n=107),年龄2个月~12岁,ASAⅡ~Ⅲ级,术后7年对患儿及家属进行随访。记录并统计分析患儿术后近远期不良事件的发生率和死亡率。结果 与对照组比较,乌司他丁组的术后总出血量显著减少,差异有统计学意义(P=0.01)。与对照组比较,乌司他丁组术后延迟拔管的发生率显著减少,差异有统计学意义(P=0.02)。两组患者间住院肾功能衰竭发生率和死亡率的差异无统计学意义(P>0.05)。术后7年两组患者肾功能衰竭和死亡的发生率差异无统计学意义(P>0.05)。结论 乌司他丁可显著降低紫绀患儿心脏术后总出血量和术后延迟拔管的发生率,具有肺保护作用,对近、远期肾功能衰竭的发生率和死亡率没有影响。
Objective To investigate the pulmonary protective effect of ulinastatin in pediatric patients undergoing radical surgery for tetralogy of Fallot (TOF) and its long-term outcomes. Methods The study was an observational cohort study. During January 2010 to December 2010, 184 consecutive patients aged from 2 months to 12 years old who received radical surgery for TOF in Fuwai hospital were enrolled in the study. They were divided into two groups: the control group (n=77) and the ulinastatin group (n=107). They were followed up for seven years. The morbidity and mortality were recorded and analyzed. Results Compared with the control group, patients in the ulinastatin group showed a significantly lower postoperative blood loss ( P =0.01) and a less prolonged mechanical ventilation ( P =0.02). There was no significant difference in postoperative and long-term mortality and morbidity between the two groups ( P >0.05). Conclusion Ulinastatin might decrease the postoperative blood loss and the incidence of prolonged mechanical ventilation. Moreover, ulinastatin did not affect the short-term and long-term incidence of renal failure and mortality in pediatric patients with cyanosis undergoing cardiac surgery.
作者
吕红
李丽
吕焕然
周勇
赵婉
张昱
Lv Hong;Li Li;Lv Huanran;Zhou Yong;Zhao Wan;Zhang Yu(Department of Anesthesiology,Fuwai Hospital,National Center for Cardiovascular Disease,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100037,China)
出处
《中国体外循环杂志》
2019年第3期153-156,共4页
Chinese Journal of Extracorporeal Circulation
关键词
乌司他丁
法洛四联症
紫绀
围手术期
肺保护
随访
Ulinastatin
Tetralogy of Fallot
Cyanosis
Perioperative period
Lung protection
Children
Follow up