孕早期血清学联合NT筛查对唐氏综合征的临床诊断价值

Clinical diagnostic value of early pregnancy serology combined with NT screening in Down′s syndrome

目的分析血清学指标联合B超测胎儿颈项透明层(NT)厚度对孕妇早期唐氏综合征(DS)的诊断效果。方法选取2017年1月~2018年3月在我院就诊的3376例孕妇作为研究对象。对产妇进行DS筛查,采取B超测胎儿NT厚度,以及血清学检测游离人体绒膜促性腺激素(β-HCG)、妊娠相关蛋白(PAPP-A)水平,分析超声NT单一检测、血清学单一检测与超声NT检测、血清学联合检测诊断结果的准确性。结果联合筛查方法得到高危异常率为7.14%,远远高于单一筛查得到的高危异常率,且通过联合筛查的方式确定产妇患有DS的风险性。结论血清学联合NT筛查的方式对DS的诊断比单一筛查的方式诊断效果更好,可更加科学准确的预测产妇不良妊娠的发生率,对于降低出生缺陷,提高人口素质有良好的临床应用价值,值得推广。

Objective To analyze the diagnostic effect of serological markers combined with B-ultrasound on the thickness of fetal neck transparent layer (NT) on early pregnant patients with Down syndrome (DS).Methods A total of 3376 pregnant women who admitted to our hospital from January 2017 to March 2018 were selected as subjects for this study.Screening for DS in the mother,taking the B-ultrasound to measure the thickness of the fetal NT,and serologically detecting the levels of free human chorionic gonadotropin (β-HCG) and pregnancy-related protein (PAPP-A).To analyze the accuracy of the diagnosis of NT screening methods,serological detection and NT screening methods combined with serology.Results The abnormal rate of high-risk patients obtained by the combined screening method was 7.14%,which was much higher than the abnormal rate of high-risk patients obtained by single screening.And determine the risk of maternal disease with DS through joint screening,and then diagnose the possibility of maternal adverse pregnancy outcomes.Conclusion Serological and NT screening methods are more effective in diagnosing DS than in single screening.It can predict the incidence of maternal adverse pregnancy more scientifically and accurately,and reduce birth defects and improve population quality,which has a good clinical application value and is worth promoting.