中西医结合促肝脏细胞再生治疗肝硬化的效果分析

Effect analysis of promoting hepatocyte regeneration by integrated traditional Chinese and western medicine in the treatment of liver cirrhosis

目的探讨中西医结合促肝脏细胞再生治疗肝硬化的效果。方法选取2013年6月~2016年10月我院收治的224例各种肝硬化失代偿期患者作为研究对象,使用随机数字表法分为试验组和对照组,每组各112例。对照组给予常规方式治疗,试验组给予中西医结合促肝脏细胞再生治疗。比较分析临床治疗效果和药物安全性,比较两组治疗后的肝功能指标和血清肝纤维化指标。结果试验组的治疗总有效率为90.18%,明显高于对照组的80.36%(P<0.05)。试验组治疗后的甲胎蛋白(AFP)水平为(17.00±2.31)U/ml,明显低于对照组的(27.00±2.34)U/ml(P<0.05);天冬氨酸氨基转移酶(AST)水平为(43.62±7.69)U/L,明显低于对照组的(86.47±12.58)U/L(P<0.05);总胆红素(TBIL)水平为(21.96±4.09)μmol/L,明显低于对照组的(64.29±9.72)μmol/L(P<0.05);肝功能白球比例(A/G)为(0.80±0.37),明显高于对照组的(0.60±0.21)(P<0.05)。试验组治疗后的透明质酸(HA)水平为(300.53±107.53)μg/L,明显低于对照组的(537.19±128.46)μg/L(P<0.05);层黏蛋白(LN)水平为(96.33±26.17)μg/L,明显低于对照组的(128.74±30.51)μg/L(P<0.05);Ⅲ型前胶原(PCⅢ)水平为(142.63±31.05)μg/L,明显低于对照组的(167.49±40.11)μg/L(P<0.05)。两组治疗后不良反应发生率比较,差异无统计学意义(P>0.05),且不良反应对症处理后消失。结论中西医结合促肝脏细胞再生治疗肝硬化临床效果显著,明显降低患者生化指标,且不良反应发生率较低,具有较高的临床应用价值。

Objective To explore the effect of promoting liver cell regeneration by integrated traditional Chinese and western medicine in the treatment of liver cirrhosis.Methods A total of 224 patients with decompensated cirrhosis from June 2013 to October 2016 were selected as the study subjects.They were divided into experimental group and control group according to random number table method,112 cases in each group.The patients in the control group were given routine treatment,while those in the experimental group were given integrated traditional Chinese and western medicine to promote liver cell regeneration.The clinical therapeutic effect and drug safety were compared and analyzed.The indexes of liver function and serum hepatic fibrosis were compared between the two groups.Results The total effective rate was 90.18% in the experimental group,which was significantly higher than 80.36% in the control group (P<0.05).After treatment,the level of alpha-fetoprotein (AFP) in the experimental group was (17.00±2.31) U/ml,which was significantly lower than that in the control group ([27.0±2.34] U/ml)(P<0.05);the level of aspartate amino transferase (AST) was (43.62±7.69) U/L,which was significantly lower than that in the control group ([86.47±12.58] U/L)(P<0.05);the level of TBIL was (21.96±4.09) mol/L,which was significantly lower than that in the control group ([64.29±9.72] mol/L)(P<0.05);the white ball ratio (A/G) was (0.80±0.37),significantly higher than that of the control group (0.60±0.21)(P<0.05).After treatment,hyaluronic acid (HA) level in the experimental group was (300.53±107.53)μg/L,significantly lower than that in the control group ([537.19±128.46]μg/L)(P<0.05);laminin (LN) level was (96.33±26.17)μg/L,significantly lower than that in the control group ([128.74±30.51]μg/L)(P<0.05);Ⅲ procollagen (PCⅢ) level was (142.63±31.05)μg/L,significantly lower than that in the control group ([167.49±40.11]μg/L)(P<0.05).There was no significant difference in the incidence of side effects between the two groups after treatment (P>0.05),and the side effects disappeared after symptomatic treatment.Conclusion The combination of traditional Chinese and western medicine in promoting liver cell regeneration in the treatment of liver cirrhosis has significant clinical effect,significantly reduces the biochemical indicators of patients,and the incidence of side effects is low,so it has high application clinical value.