老年COPD患者急性期P物质检测的临床意义

Clinical significance of COPD in the elderly patients with P in acute phase

目的探讨老年慢性阻塞性肺病(COPD)急性发作时检验其P物质的临床意义。方法选取2016年2月至2017年10月在我院接受治疗的COPD老年患者,其中急性期COPD患者42例作为A组,35例稳定期COPD老年患者作为B组,同期30例健康老年人作为C组,采用ELISA检测P物质水平,计算COPD病情及预后预测指标BODE指数得分,分析两者的相关性。结果COPD急性期和稳定期患者P物质水平均高于健康老年人(P<0.05),且急性期患者高于稳定期患者(P<0.05);A组和B组患者血浆P物质水平均与BODE指数得分成正相关(P<0.05)。结论 通过检验老年COPD急性发作期患者血浆P物质水平可以较准确地判断病情和预后,对临床诊断和治疗提供了一定指导。

Objective To investigate the clinical significance of P in the acute exacerbation of chronic obstructive pulmonary disease (COPD) in elderly patients. Methods From February 2016 to October 2017 in our hospital received treatment of COPD elderly patients,including 42 patients with acute phase A as COPD group,35 patients with stable COPD elderly patients as B group,30 cases of healthy elderly as C group,the ELISA detection of P levels,COPD disease and prognosis prediction index BODE index score,analysis of the correlation. Results Substance P levels in patients with COPD were significantly higher than those in healthy elderly patients (P<0.05),and the patients with acute phase were higher than those in stable patients (P<0.05).The levels of plasma P in patients with A and B were positively correlated with BODE index (P<0.05). Conclusion The level of plasma P in the elderly patients with acute exacerbation of COPD can be more accurate to judge the disease and prognosis,and provide some guidance for clinical diagnosis and treatment.