老年肺部感染患者病原菌分布及耐药性分析

Distribution and drug resistance of pathogenic bacteria in elderly patients with pulmonary infection

目的通过对老年肺部感染患者病原菌分布及耐药性的分析,以便指导临床一线医生经验用药。方法选取2017年1月到2018年12月北京小汤山医院综合内科(护理中心)收治的老年肺部感染患者165例,对患者进行细菌培养及药敏试验,分析感染患者的病原菌分布及耐药性。结果165例老年肺部感染患者共检出病原菌数量237株,其中革兰阴性菌188株,占79.33%,排在前三位分别为铜绿假单胞菌、大肠埃希菌和肺炎克雷伯菌,分别为88株、24株、24株,占37.13%、10.13%、10.13%;革兰阳性菌48株,占20.25%;以金黄色葡萄球菌为主,25株,占10.5%;真菌1株,为白假丝酵母,占0.42%。结论 革兰阴性菌为老年肺部感染患者主要致病菌,主要的革兰阴性菌对妥布霉素、庆大霉素敏感,主要革兰阳性菌对替加环素、万古霉素敏感。

Objective To analyze the distribution of pathogenic bacteria and drug resistance in elderly patients with pulmonary infection in order to guide the clinical experience of first-line doctors. Methods 165 patients with pulmonary infection were selected from January 2017 to December 2018 in Beijing xiaotangshan hospital.Bacterial culture and drug sensitivity test were carried out to analyze the pathogen distribution and drug resistance of infected patients. Results A total of 237 pathogenic bacteria were detected in 165 elderly patients with pulmonary infection,of which 188 were gram-negative,accounting for 79.33 %.The top three were Pseudomonas aeruginosa,Escherichia coli,and Feiyankeleibojun,respectively.88,24,24,accounting for 37.13 %,10.13 %,and 10.13 %;48 Gram-positive bacteria,accounting for 20.25 %;Staphylococcus aureus,25 strains,accounting for 10.5 %;Fungal 1 plant,white pseudoyeast,accounting for 0.42 %. Conclusion Gram-negative bacteria are the main pathogenic bacteria in elderly patients with pulmonary infection.The main Gram-negative bacteria are sensitive to tobramycin and gentamicin,and the main Gram-positive bacteria are sensitive to tikacycline and vancomycin.