血清IL-6、IL-8、TNF-α在COPD患者肺癌辅助诊断中的价值分析

The value of serum IL-6,IL-8 and TNF-α in the assisted diagnosis of lung cancer in COPD patients

目的:分析血清白细胞介素-6(IL-6)、IL-8、肿瘤坏死因子-α(TNF-α)在慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者肺癌辅助诊断中的价值。方法:选取41例COPD合并肺癌患者作为研究组,41例COPD稳定期患者作为对照组。检测并分析两组患者血清IL-6、IL-8、TNF-α水平。结果:研究组血清IL-6、IL-8、TNF-α水平均高于对照组,差异有统计学意义(P<0.05)。COPD患者合并肺癌的发生与血清IL-6、IL-8、TNF-α水平均具有相关性(P<0.05)。血清IL-6、IL-8、TNF-α水平诊断COPD患者合并肺癌的受试者工作特征曲线下面积(AUC)分别为0.783、0.830、0.677(P<0.05);其中,以血清IL-8的AUC最高,在Cutoff值下,灵敏度和特异度分别为0.732和1.000,当将这3种血清指标进行联合检测时,AUC未获得提高。结论:相对于COPD稳定期患者,COPD合并肺癌患者表现为血清IL-6、IL-8、TNF-α水平更显著上升;其中,血清IL-6、IL-8水平能够较好地用于COPD合并肺癌的辅助诊断,临床上应对COPD患者的血清炎症因子水平进行有效监测,以提高肺癌的早期诊断效率。

Objective:To analyze the value of serum interleukin-6 (IL-6),interleukin-8 (IL-8) and tumor necrosis factor-α(TNF-α) in the auxiliary diagnosis of lung cancer in patients with chronic obstructive pulmonary disease (COPD).Methods:41 COPD patients with lung cancer were selected as the study group,and 41 COPD patients with stable stage were selected as the control group.Serum levels of IL-6,IL-8 and TNF-α were detected and analyzed in the two groups.Results:The serum levels of IL-6,IL-8 and TNF-α in the study group were higher than those in the control group,and the difference between the two groups was statistically significant ( P <0.05).The incidence of lung cancer in COPD patients was correlated with serum levels of IL-6,IL-8 and TNF-α( P <0.05).Serum IL-6,IL-8 and TNF-α levels were 0.783,0.830 and 0.677 ( P <0.05),respectively,under the working characteristic curve(AUC) of COPD patients with lung cancer.The AUC of serum IL-8 was the highest,and the sensitivity and specificity of serum IL-8 were 0.732 and 1.000 under cutoff value.When combined detection of the three serum indicators,AUC did not improve.Conclusion:Compared with COPD patients in stable stage,the serum levels of IL-6,IL-8 and TNF-α in COPD patients with lung cancer increased significantly.Serum levels of IL-6 and IL-8 can be better used in the auxiliary diagnosis of COPD patients with lung cancer.The levels of serum inflammatory factors in COPD patients should be effectively monitored in order to improve the early diagnosis efficiency of lung cancer.