不同营养素对活动期溃疡性结肠炎患者肠道生物屏障的影响

Effects of diverse nutrient on intestinal biologic barrier of patients with active ulcerative colitis

目的研究不同营养素配方对溃疡性结肠炎活动期肠道生物屏障的干预作用,探讨不同配方用于溃疡性结肠炎活动期治疗的可行性。方法将79例活动期溃疡性结肠炎患者采用数字表法随机分为5组,常规组、肠内营养组、微生态制剂组、免疫增强剂组和微生态免疫增强肠内营养组。应用细菌培养法于治疗前后分别测定各组调查对象的大便,计数治疗前后乳酸杆菌、双歧杆菌、肠球菌、肠杆菌及酵母菌,比较各组的肠道菌群构成的差异,并观察患者病情缓解情况。结果常规组可改善肠道菌群失调,微生态制剂组和免疫增强剂组的作用优于常规组但差异无统计学意义,肠内营养组及微生态免疫增强肠内营养组疗效均优于常规组,且差异有统计学意义,微生态免疫增强肠内营养组作用最优。结论在活动期溃疡性结肠炎患者中应用不同营养素配方能够增强对肠道菌群失调的改善作用,进而保护活动期溃疡性结肠炎患者肠道生物屏障。

Objective To evaluate the intervene effect of diverse nutrient on intestinal biologic barrier and the feasibility of applying diverse nutrient recipe in patients with acute ulcerative colitis(UC).Methods Totally 79 patients enrolled were randomly assigned to five groups,traditionary group(T-group),enteral nutrition group(E-group),microecologicalagent group(ME-group),immunostimulants group(IS-group),immune-enhanced enteral nutrition group(IEEN-group).Germiculture was used to detect the stool of all subjects before and after treatment,and the number of Bacterium lacticum,Bifidobacterium,Enterococci,Entericbacilli and yeasts were counted,then to compare the differences of intestinal flora composition and observe the remission situation.Results The clinical efficacy of the IEEN-group was better than that in the T-group.The improvement of intestinal flora of the IEEN-group was the best,then the E-group,then the ME-group and IS-group,the T-group was the last.The IEEN-group and the E-group may be beneficial to UC patients.Conclusion Application of different nutrient formulations in patients with active ulcerative colitis can improve the intestinal flora imbalance and protect intestinal barrier in patients with active ulcerative colitis.