二丁酰环磷腺苷钙联合伊伐布雷定对慢性心力衰竭的疗效

Study on efficacy of dibutyryl cyclic adenosine phosphate combined with ivabradine in the treatment of chronic heart failure

目的研究二丁酰环磷腺苷钙联合伊伐布雷定治疗慢性心力衰竭的效果。方法选择96例慢性心力衰竭患者,随机分为两组。在常规治疗的基础上,对照组采用二丁酰环磷腺苷钙治疗,观察组采用二丁酰环磷腺苷钙联合伊伐布雷定治疗。比较两组的总有效率,治疗前后的心功能、血清学指标。结果观察组的治疗总有效率明显高于对照组(P<0.05);治疗后,两组的NT-proBNP、HR、CRP明显降低(P<0.05),LVEF明显升高(P<0.05),且观察组的改善幅度大于对照组(P<0.05);治疗期间,两组的头痛、眼内闪光、心动过缓、胆红素升高发生率比较无明显差异(P>0.05)。结论二丁酰环磷腺苷钙联合伊伐布雷定治疗心衰的效果较佳,能有效改善心功能,降低炎性反应,且安全性较高。

Objective To study the efficacy of dibutyryl cyclic adenosine phosphate combined with ivabradine in the treatment of chronic heart failure.Methods A total of 96 patients with chronic heart failure were selected and randomly divided into a control group and an observation group.On the basis of conventional treatment,the control group was treated with dibutyryl cyclic adenosine phosphate,and the observation group was treated with dibutyryl cyclic adenosine phosphate combined with ivabradine.The total effective rates,heart functions and serum indexes before and after treatment were compared.Results The total effective rate in the observation group was significantly higher than that in the control group(P<0.05).After treatment,the NT-pro BNP,HR and CRP in both groups were significantly lower(P<0.05),while the LVEF was significantly higher(P<0.05),and more significant in the observation group(P<0.05).During treatment,there was no difference in the incidences of headache,intraocular flash,bradycardia and increased bilirubin between the two groups(P>0.05).Conclusion Dibutyryl cyclic adenosine phosphate combined with ivabradine is a better and safer resort to treat heart failure by effectively improving heart function and inhibiting inflammatory reaction.