放疗加紫杉醇周疗在局部晚期宫颈癌中的临床应用

Clinical application of radiotherapy and paclitaxel weekly therapy in locally advanced cervical cancer

目的探讨小剂量紫杉醇周疗联合放疗与单纯放射治疗中晚期宫颈癌的疗效和毒副反应。方法回顾性分析我院近年来收治的144例中晚期宫颈癌患者的临床资料。两组同样的放疗方法及剂量,同步放化疗组给予紫杉醇40mg/m^2周疗,共6次,比较两组的治疗效果及不良反应。结果同步放化疗组的有效率、3年生存率、局部复发率、远处转移率分别为90.8%、77.8%、11.8%、7.9%,单纯放疗组的有效率、3年生存率、局部复发率、远处转移率分别为69.1%、57.7%、20.6%、16.2%,两组差异有统计学意义(P<0.05)。两组不良反应发生率差异无统计学意义(P>0.05)。结论放疗加紫杉醇周疗能提高中晚期宫颈癌的疗效和生存率,毒副反应与单纯放疗组相比无明显增加。

Objective To investigate the efficacy and side effects of low-dose paclitaxel weekly therapy combined with radiotherapy and radiotherapy alone for middle and advanced cervical cancer. Methods The clinical data of 144 patients with middle and advanced cervical cancer admitted in our hospital in recent years were retrospectively analyzed. The same radiotherapy method and dose were given in the two groups. The concurrent radiotherapy and chemotherapy group was given paclitaxel 40 mg/m^2 weekly therapy for a total of 6 times. The therapeutic effects and adverse reactions of the two groups were compared. Results The effective rate, 3-year survival rate, local recurrence rate, and distant metastasis rate of the concurrent radiotherapy and chemotherapy group were 90.8%, 77.8%, 11.8%, and 7.9%, respectively. The effective rate, 3-year survival rate, local recurrence rate, and distant metastasis rate of the radiotherapy group were 69.1%, 57.7%, 20.6%, and 16.2%, respectively. The difference was statistically significant between the two groups(P<0.05). There was no significant difference in the incidence of adverse toxic side effects between two groups(P>0.05). Conclusion Radiotherapy and paclitaxel weekly therapy can improve the efficacy and survival rate of middle and advanced cervical cancer, and the toxicity and side effects of the combined treatment are not significantly increased compared with those in the radiotherapy alone group.