Notch受体在胃癌中的表达及其临床意义

Expressions of Notch receptors in gastric cancer and their clinical significances

目的探讨胃癌组织中Notch受体的表达及其与临床病理特征及预后的关系。方法采用免疫组织化学SP法检测湖南中医药大学第三附属医院2014年1月至2015年5月45例手术治疗的胃癌患者标本中Notch1、Notch2、Notch3、Notch4相应受体表达情况,分析Notch受体表达与淋巴结转移、TNM分期及无病生存(DFS)、总生存(OS)的关系。结果 Notch1、Notch2、Notch3、Notch4相应受体主要分布在细胞质中,在胃癌组织中的阳性表达率分别为93.3%(42/45)、86.7%(39/45)、80.0%(36/45)、77.8%(35/45),均高于癌旁组织[31.1%(14/45)、24.4%(11/45)、40.0%(18/45)、46.7%(21/45)],差异均有统计学意义(均P<0.05)。胃癌组织Notch1、Notch2、Notch3、Notch4相应受体表达与患者淋巴结转移状态、TNM分期、DFS、OS均无相关性(均P>0.05)。结论 Notch受体在胃癌组织中高表达,与患者淋巴结转移、TNM分期及术后患者DFS、OS均无相关性。

Objective To investigate the expression of Notch receptors and its relationship with clinicopathological features and prognosis in gastric cancer tissues. Methods Immunohistochemical SP method was used to detect the expression levels of Notch1, Notch2, Notch3 and Notch4 corresponding receptors in 45 patients with gastric cancer from January 2014 to May 2015 in the Third Affiliated Hospital of Hunan University of Traditional Chinese Medicine. The correlation between expression levels of Notch receptors and lymph node metastasis, TNM staging, disease-free survival (DFS) and overall survival (OS) were analyzed. Results Notch1, Notch2, Notch3 and Notch4 corresponding receptors were mainly distributed in the cytoplasm, and the positive expression rates in gastric cancer tissues were 93.3%(42/45), 86.7%(39/45), 80.0%(36/45), and 77.8%(35/45), which were higher than those in adjacent tissues [31.1%(14/45), 24.4%(11/45), 40.0%(18/45), and 46.7%(21/45)], and the differences were statistically significant (all P < 0.05). There was no correlation between the expression of Notch1, Notch2, Notch3 and Notch4 corresponding receptors and lymph node metastasis, TNM staging, DFS and OS in gastric cancer tissues (all P > 0.05). Conclusion Notch receptors are highly expressed in gastric cancer tissues, and have no correlation with lymph node metastasis, TNM staging, DFS and OS of patients after surgery.