他克莫司治疗炎症性肠病的最新进展

Advances in research of tacrolimus for treatment of inflammatory bowel disease

炎症性肠病(inflammatory bowel disease, IBD)的传统用药包括氨基水杨酸制剂、糖皮质激素、免疫抑制剂如硫嘌呤类、环孢素等药物.近十多年来,抗肿瘤坏死因子药物(anti-tumor necrosis factor, anti-TNF)的应用使IBD患者的临床缓解方面取得了显著进展,但其仍然存在无反应、无法耐受和停用后复发等问题.近些年来发现,他克莫司,一种新型强效免疫抑制剂,作为治疗IBD的二线治疗药物被使用.目前,他克莫司的短期诱导缓解作用相对明显,被逐渐应用在传统药物难治或者anti-TNF难治的IBD中.少数研究发现,在适当的监测下,他克莫司可以长期安全地使用.但其长期疗效和长期使用安全性的证据还比较少.本文就他克莫司在IBD中的治疗最新进展及其与anti-TNF的比较作一综述.

Traditional drugs for inflammatory bowel disease (IBD) include aminosalicylic acid preparations, glucocorticoids, and immunosuppressive agents such as thiopurine and cyclosporine. In recent ten years, the application of anti-tumor necrosis factor (anti-TNF) drugs has greatly improved the clinical remission of patients with IBD, but there are still some problems, such as no response, intolerance, and recurrence after withdrawal. In recent years, tacrolimus, as a new powerful immunosuppressive agent, has been used as a second-line therapeutic drug for IBD. At present, the tacrolimus induced short-term remission effect in IBD is relatively obvious, and it has been gradually used for treatment of IBD refractory to traditional drugs or anti-TNF drugs. A few studies have found that tacrolimus can be used safely for a long time under proper monitoring. However, there is little evidence of long-term efficacy and safety. In this paper, we review the latest advances in the treatment of IBD with tacrolimus and make a comparison with anti-TNF drugs.