摘要
食管微生态是一个新兴的研究领域,目前的研究发现食管具有多样化的常驻菌群,食管疾病病程中常伴有食管菌群结构的改变,牙周致病菌与食管癌发病高风险密切相关.菌群失调介导的炎性免疫反应可能是促进食管疾病发生和发展的机制之一.本文综述了正常和疾病状态下的食管菌群特征,旨在为寻找基于微生态的食管疾病干预策略提供新思路.
The microbiota of the esophagus has been the least systematically studied among the organs of the gastrointestinal tract. Esophageal microbiota has been proved to be complex with a high diversity until recently. Alterations of its composition are associated with the development and progression of esophageal diseases. Immunoinflammatory responses caused by dysbiosis may play a role in the pathogenesis of esophageal disorders. This review addresses the characteristics of esophageal microbiota in physiological and pathological conditions, aiming to provide new insights into esophageal microecology-based intervention strategies for esophageal diseases.
作者
马双
王赛宇
朱兰平
陈鑫
王邦茂
Shuang Ma;Sai-Yu Wang;Lan-Ping Zhu;Xin Chen;Bang-Mao Wang(Department of Gastroenterology and Hepatology, General Hospital of Tianjin Medical University, Tianjin 300052, China)
出处
《世界华人消化杂志》
CAS
2019年第12期767-772,共6页
World Chinese Journal of Digestology
基金
天津市科技计划项目,No.15ZXJSY00020
天津医科大学总医院青年孵育基金,No.2YYFY2016029~~
