消瘿合剂对甲状腺功能正常育龄期女性桥本甲状腺炎患者甲状腺自身抗体的影响

Effects of Xiaoying Mixture on thyroid autoantibodies in Hashimoto thyroiditis in women of child-bearing potential with normal thyroid function

目的观察消瘿合剂对早期桥本甲状腺炎(HT)育龄期女性患者甲状腺自身抗体的影响。方法采用随机、双盲、安慰剂平行对照的方法,将符合纳入标准的64例HT女性患者分为治疗组和对照组,每组32例。治疗组患者给予消瘿合剂口服,对照组患者给予安慰剂口服,两组治疗周期均为12周。治疗前后检测两组患者的血清甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TGAb)滴度及性激素包括促卵泡激素(FSH)、促黄体生成激素(LH)、雌二醇(E2)、孕酮(P)、睾酮(T)、泌乳素(PRL)水平,记录两组患者的月经和妊娠情况。结果治疗后,治疗组患者的TPOAb水平较治疗前明显下降(P<0.05),且两组患者TPOAb治疗前后差值比较,其差异有统计学意义(P<0.05)。治疗前后,两组患者的TGAb及FSH、LH、E2、P、T、PRL水平比较,差异均无统计学意义(P>0.05)。治疗前后两组患者的月经异常情况比较,差异均无统计学意义(P>0.05)。在试验期间,两组均无患者出现新发妊娠或不良妊娠结局。结论消瘿合剂可降低HT育龄期女性患者的甲状腺自身抗体滴度,但对其月经情况及妊娠不良结局方面的影响未见明显阳性结果。

Objective To observe the effects of Xiaoying Mixture on thyroid autoantibodies in early Hashimoto thyroiditis ( HT) in women of child- bearing potential. Methods A randomized,double-blind,parallel-group,placebo-controlled study was conducted,in which 64 women with HT who met the inclusion criteria were assigned into treatment group and control group,32 patients in each group. The treatment group was treated with Xiaoying Mixture and the control group was given placebo. The treatment course was 12 weeks in both groups. Titers of thyroid peroxidase antibody ( TPOAb) and thyroglobulin antibody ( TGAb) and levels of sex hormones including follicle stimulating hormone ( FSH),luteinizing hormone ( LH),estradiol ( E2 ), progesterone ( P),testosterone ( T) and prolactin ( PRL) were measured before and after treatment. Menstruation and pregnancy were recorded in both groups. Results After treatment,the level of TPOAb in the treatment group was significantly lower than that before treatment ( P<0.05),and there was statistically significant difference between the groups ( P>0.05). Before and after treatment,there was no significant difference in the levels of TGAb, FSH,LH,E2,P,T or PRL between the groups ( P>0.05). Before and after treatment,there was no significant difference in abnormal menstruation between the groups ( P>0.05). During the trial,there was no new pregnancy or adverse pregnancy outcomes in either group. Conclusion Xiaoying Mixture reduces the titer of thyroid autoantibodies in HT in women of child-bearing potential,but there are no significant positive results in menstruation and adverse pregnancy outcomes.