摘要
N-烯丙基芳胺在非金属催化条件下,发生多氯甲基化/环化串联反应生成多氯甲基取代的吲哚啉.该反应以非活化的烯烃为自由基受体,过氧化二异丙苯(DCP)为引发剂,廉价的二氯甲烷、氯仿、四氯化碳溶剂作为二氯甲基化或三氯甲基化试剂,且具有操作简单、条件温和、成本低、底物适用范围广等优点.
A metal-free polychloromethylation/cyclization cascade of N-allyl anlines is presented,which provides an access to polychloromethyl-substituted indolines with unactivated alkenes as radical acceptors and dicumyl peroxide(DCP)as the initiator.The inexpensive solvents of polychoromethanes(i.e.,CH2Cl2,CHCl3 and CCl4)were used in the reaction as di-or trichloromethylating agents.This work has advantages of easy operation,mild conditions,low cost,and broad substrate scope.
作者
李文兰
孙一茼
姚永超
许颖
李鹏
刘颖杰
梁德强
Li Wenlan;Sun Yitong;Yao Yongchao;Xu Ying;Li Peng;Liu Yingjie;Liang Deqiang(Research Center on Life Sciences and Environmental Sciences,Harbin University of Commerce,Harbin 150076;Department of Chemistry,Kunming University,Kunming 650214;Heilongjiang Nursing College,Harbin 150000)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2019年第6期1727-1734,共8页
Chinese Journal of Organic Chemistry
基金
Project supported by the National Natural Science Foundation of China(No.21702083)
the Program for Innovative Research Team(in Science and Technology)in Universities of Yunnan Province
the Program of Young Innovators of Education Department of Heilongjiang Province(No.UNPYSCT-2016181)
the Innovation Talents Foundation of Harbin of China(No.2015RAQXJ061)~~
关键词
非活化烯烃
多氯甲基化
吲哚啉
自由基反应
unactivated alkenes
polychloromethylation
indolines
radical reaction
