钌催化下吡唑基导向的1-苄基-1H-吡唑的C(sp^2)-H键烯基化和烷基化反应

Ruthenium-Catalyzed C(sp^2)-H Alkenylation and Alkylation of 1-Benzyl-1H-pyrazole under Assistance of Pyrazole Group

发展了一种吡唑基导向的钌催化的1-苄基-1H-吡唑与烯烃或a,β-不饱和酮的C(sp^2)-H键烯基化和烷基化反应.该反应具有较好的选择性,烯基化和烷基化选择性地发生在苄基的邻位.为1-苄基-1H-吡唑的官能团化提供了一种有效方法.

A practical ruthenium-catalyzed C(sp^2)-H alkenylation and alkylation of 1-benzyl-1H-pyrazole with alkene or a,β-unsaturated ketones under the assistance of pyrazole group were developed.This method has the advantages of high selectivity,providing only the ortho-alkenylation or ortho-alkylation products in high yields.This protocol provides an efficient and new method for the functionalization of 1-benzyl-1H-pyrazoles.