锡粉促进下α-三氟甲基高烯丙基酰肼的合成（英文）

Tin Powder Promoted Synthesis of α-Trifluoromethyl Homoallylic Hydrazides

探索了在布朗斯特酸和路易斯酸作用下,以1,4-二氧六环为溶剂,由三氟丙酮酸乙酯、酰肼、烯丙基溴和锡粉在回流条件下一锅法合成α-三氟甲基高烯丙基酰肼的方法.该方法避免了使用有毒的有机锡试剂,并且操作简单,反应条件温和,以良好的收率得到其相应的产物.

An efficient multicomponent one-pot reaction was developed for the synthesis ofα-trifluoromethyl homoallylic hydrazides from the reactions of ethyl trifluoropyruvate,hydrazides and allylic bromide with tin powder in the presence of Bronsted and Lewis acid in 1,4-dioxane under reflux.The method avoids the use of toxic stannanes and allows easy operation.The reaction proceeds smoothly under mild reaction conditions to give the corresponding products in good yields.