摘要
BACKGROUND Orthokeratinized odontogenic cyst (OOC) is a benign odontogenic cyst. It is a variant of the common odontogenic keratocyst (OKC). This case report describes a rare malignant transformation of OOC, with the aim of raising awareness of the malignant potential of OOC and distinguishing it from OKC. CASE SUMMARY In August 2018, a 52-year-old man was referred to the Department of Oral Maxillofacial and Head–Neck Oncology of Wuhan University. The patient presented with severe pain in the left mandible for 2 mo, and had a 5-year history of osteomyelitis and mandibular cyst with three recurrences. His latest diagnosis by pathological examination was OOC of the left mandible with mild-tomoderate local proliferation. However, the cyst showed malignant potential by radiographic examination. We performed partial mandibulectomy and sent the lesion tissue for pathological examination. As expected, the cyst had deteriorated to moderately differentiated squamous cell carcinoma. During postoperative follow-up, the patient went for chemotherapy in September 2018 and successfully completed four cycles. CONCLUSION Surgeons should be more aware of OOC, which is usually benign but can become malignant.
BACKGROUND Orthokeratinized odontogenic cyst(OOC)is a benign odontogenic cyst.It is a variant of the common odontogenic keratocyst(OKC).This case report describes a rare malignant transformation of OOC,with the aim of raising awareness of the malignant potential of OOC and distinguishing it from OKC.CASE SUMMARY In August 2018,a 52-year-old man was referred to the Department of Oral Maxillofacial and Head-Neck Oncology of Wuhan University.The patient presented with severe pain in the left mandible for 2 mo,and had a 5-year history of osteomyelitis and mandibular cyst with three recurrences.His latest diagnosis by pathological examination was OOC of the left mandible with mild-tomoderate local proliferation.However,the cyst showed malignant potential by radiographic examination.We performed partial mandibulectomy and sent the lesion tissue for pathological examination.As expected,the cyst had deteriorated to moderately differentiated squamous cell carcinoma.During postoperative follow-up,the patient went for chemotherapy in September 2018 and successfully completed four cycles.CONCL USION Surgeons should be more aware of OOC,which is usually benign but can become malignant.
基金
Supported by Wuhan Morning Light Plan of Youth Science and Technology,No.2017050304010305
National Natural Science Foundation of China,No.81702705
