摘要
糖尿病前期(prediabetes,pre-DM)为血浆葡萄糖水平在正常血糖和糖尿病之间的一种中间状态,是正常向糖尿病发病过程中的分水岭。pre-DM病因复杂,停靠蛋白1(docking protein 1,DOK1)可通过Akt/SREBP1c信号通路、Akt/GSK-3信号通路和Akt/NF-kB信号通路在pre-DM的致病过程中发挥重要作用。
Prediabetes(pre-DM) is defined as an intermediate state of plasma glucose levels between normal blood glucose and diabetes.which is a watershed between normal and diabetes.The pathogenesis of pre-DM is plentiful.The possible mechanism of pre-DM is complex,the docking protein 1(DOK1) plays an important role in the pathogenesis of pre-DM through the Akt/SREBP1c signaling pathway,Akt/GSK-3 signaling pathway and Akt/NF-kB signaling pathway.
作者
蔡小玲
蒋如如
李洁
李欣
杨波
哈小琴
CAI Xiaoling;JIANG Ruru;LI Jie;LI Xin;YANG Bo;HA Xiaoqin(Department of Medical Laboratory,Qinghai Provincial People′s Hospital, Xining 810007,China;Department of Medical Laboratory,the 940th Hospital of Joint Logistic Support Force of PLA;Gansu University of Chinese Medicine)
出处
《西北国防医学杂志》
CAS
2019年第6期387-390,共4页
Medical Journal of National Defending Forces in Northwest China
基金
甘肃省重点研发项目(17YF1FA135)
