碱催化法合成丙硫菌唑

Synthesis of Prothioconazole by Base Catalysis

以2-(1-氯环丙基)-1-(2-氯苯基)-3-(1,2,4-三唑烷-5-硫酮-1-基)-2-丙醇为原料a,氢氧化钠为催化剂,空气为氧化剂,在甲醇中合成丙硫菌唑.其中,原料a∶氢氧化钠=1∶1;甲醇/原料a(V/m)=3;空气过量;反应温度35℃;反应时间4h.反应后处理加盐酸调pH至3,甲苯反萃取、重结晶得到丙硫菌唑,含量≥98%,折百收率≥90%.

Prothioconazole was synthesized using 2-( 1 -chlorcyclopropyl)-1 -(2-chlorphenyl)-3-(1,2,4-triazolidin- 5-thiono-1 -yl )-2-propanol as starting material, sodium hydroxide as catalyst, via air oxidation reaction in methanol. The reaction proceeded at 35℃ for 4 h. As a result, the purity of product is more than 98% and yield is greater than 90% by the recrystallization in toluene.